Peptide Tools to Study SARS-CoV-2

JPT has launched a broad development program to provide access to genome spanning SARS-CoV-2 peptide tools and its different mutation variants for applications such as:

  • SARS-CoV-2 clinical trial immune monitoring
  • SARS-CoV-2 evaluation of cross reactivities
  • SARS-CoV-2 blood and sero test development
  • SARS-CoV-2 T-and B-cell epitope discovery

We have broadened our portfolio of coronavirus related products beyond SARS-CoV-2, including SARS-CoVMERS-CoV and common cold viruses CoV 229E, OC43, HKU1 and NL63. Have a look below!


About SARS-CoV-2

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), the causative agent of Covid-19, is responsible for the current pandemic. Developing and monitoring vaccines, therapies and diagnostic tests that are safe, effective, and rapidly deployable is an urgent global health priority.
Check our SARS-CoV-2 Flyer

SARS-CoV-2 Variants

Alpha

Alpha

WHO Designation

Variant of Concern 202012/01, abbreviated VOC-202012/01 (also known as 20I/501Y.V1)


Alternative names

Lineage B.1.1.7, UK variant, British variant, Kent variant, Alpha

First publication

Chand et al, Public Health England (December 2020)

Reference sequences given in literature

EPI_ISL_601443
EPI_ISL_581117

Sequence used for library generation

EPI_ISL_601443 (Gisaid accession ID)

JPT’s products

PepMix™ SARS-CoV-2 (S-RBD B.1.1.7 / Alpha) : Spike receptor binding domain

Mutations

H0069-; V0070-; Y0144-; N0501Y; A0570D; D0614G; P0681H; T0716I; S0982A; D1118H
These mutations characterize approx. 86.8 % of all sequences in the B.1.1.7 lineage.

Variants pertaining to Alpha may include these additional mutations:
L0005F, V0006A, S0012F, L0018F, T0020I, R0021T, T0022I, H0049Y, A0067S, A0067V, S0071F, T0076I, P0082L, S0094F, T0095I, E0096D, S0098F, R0102I, D0138H, V0143F, H0146Q, S0151G, W0152R, L0176F, E0180G, R0214L, D0215Y, L0216F, S0221L, A0222V, H0245Y, S0255F, G0261A, A0262-, D0287G, V0289I, T0299I, T0307I, V0308L, T0323I, N0354D, N0394Y, A0475V, E0484K, S0494P, T0572I, A0575S, E0583D, V0622F, A0623S, A0626T, S0640F, Q0675H, Q0677H, T0678I, S0680F, P0681R, A0688V, A0701V, A0706V, T0732I, M0740V, R0765C, P0812S, I0818V, A0831V, K0835R, A0879V, A0892V, I0909V, L0938F, S0939F, G0946V, A1020V, V1129I, E1188D, K1191N, I1227M, V1228L, M1237I, C1243F, P1263L
Beta

Beta

WHO Designation
Variant of Concern

Alternative Names 
501Y.V2 variant, 20H/501Y.V2, 20C/501Y.V2, B.1.351 lineage, South African variant, Beta

First publication
Tegally et al, MedRxiv (December 2020)

Reference sequences given in literature
Most frequent sequence from publication above

Sequence used for library generation
EPI_ISL_700428 (Gisaid accession ID)
Wikipedia

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.351 / Beta) : Spike receptor binding domain


Mutations in spike glycoprotein
D0080A, D0215G, L0242-, A0243-, L0244-, K0417N, E0484K, N0501Y, D0614G, A0701V
This variant is annotated in the GISAID database 2008 times. An additional variant with the L18F mutation is described 1769 times. (June 13, 2021)
The mutational frequency in 190 sequences from the original paper is shown here.
The R246I mutation is found mainly in sequences with long undefined stretches and does therefore not cluster. Since it is a minor mutation we did not consider it.

Delta

Delta

WHO Designation
Variant of Concern

Alternative names
G/478K.V1, 20A/S:478K, Indian Variant, Delta

First publication
Cherian et al, Microorganisms (2021)

Reference sequences given in literature
GISAID sequences based on mutations given at SARS-CoV-2 Variant Classifications and Definitions of CDC - U.S. Department of Health & Human Services
Wikipedia

Sequence used for library generation
EPI_ISL_1969243 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.617.2 / Delta) : Spike receptor binding domain

Mutations in Spike Glycoprotein
T0019R; G0142D, E0156-, F0157-, R0158G, L0452R, T0478K, D0614G, P0681R, D0950N

Epsilon

Epsilon

WHO Designation
Formerly Monitored Variant

Alternative names
CAL.20C, Los Angeles Variant, Epsilon

First publication
Zhang et al, JAMA (February 2021)

Reference sequences given in literature
GISAID sequences based on mutations given in the reference above

Sequence used for library generation
EPI_ISL_755187 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.429 / Epsilon) : Spike receptor binding domain

Mutations in spike glycoprotein
S0013I, W0152C, L0452R, D0614G
This variant is annotated in the GISAID database 12614 times (status June 13, 2021).

Gamma

Gamma

WHO Designation
Variant of Concern

Alternative names
B.1.1.248, B.1.1.28.1, 20J/501Y.V3, Brazil(ian) variant, Gamma

First publication
National Institute of Infectious Diseases Japan (January 2021)

Reference sequences given in literature
EPI_ISL_792680 to EPI_ISL_792683

Sequence used for library generation
EPI_ISL_792680 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD P.1 / Gamma) : Spike receptor binding domain

Mutations in spike glycoprotein
L0018F, T0020N, P0026S, D0138Y, R0190S, K0417T, E0484K, N0501Y, D0614G, H0655Y, T1027I, V1176F

Kappa

Kappa

WHO Designation
Formerly Monitored Variant

Alternative names
G/452R.V3, Indian Variant, Kappa

First publication
Cherian et al, BioRxiv (May 2021)

Reference sequences given in literature
GISAID sequences based on mutations given at SARS-CoV-2 Variant Classifications and Definitions of CDC - U.S. Department of Health & Human Services

Sequence used for library generation
EPI_ISL_1372093 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.617.1 / Kappa) : Spike receptor binding domain

Mutations in spike glycoprotein
T0095I, G0142D, E0154K, L0452R, E0484Q, D0614G, P0681R, Q1071H

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Lambda

Lambda

WHO Designation
Variant of Interest

First publication
Edition 44, published June 15, 2021

Reference sequences given in literature
GISAID sequences based on mutations given in 
Kimura et al, BioRxiv (July 2021)

Sequence used for library generation
EPI_ISL_2158693 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (Spike C.37 / Lambda) : Spike receptor binding domain

Mutations
G0075V; T0076I; RSYLTPGD0246-0253N (R0246-; S0247-; Y0248-; L0249-; T0250-; P0251-; G0252-; D0253N); L0452Q; F0490S; D0614G; T0859N

Omicron BA.1

Omicron BA.1

WHO Designation
Variant of Concern

Reference publication

Sequence used for library generation
EPI_ISL_6752027 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.1.529 / Omicron) : Spike receptor binding domain


Mutations
A0067V; H0069del; V0070del; T0095I; G0142D; V0143del; Y0144del; Y0145del; N0211I*; L0212V*; V0213R*; R0214EPE*; G0339D; S0371L; S0373P; S0375F; K0417N; N0440K; G0446S; S0477N; T0478K; E0484A; Q0493R; G0496S; Q0498R; N0501Y; Y0505H; T0547K; D0614G; H0655Y; N0679K; P0681H; N0764K; D0796Y; N0856K; Q0954H; N0969K; L0981F;
* also annotated as N0211del, L0212I, ins0214EPE

Omicron BA.2

Omicron BA.2

WHO Designation
Variant of Concern

Reference publication

Sequence used for library generation
EPI_ISL_8459223 (Gisaid accession ID)

JPT’s products

PepMix™ SARS-CoV-2 (NCAP B.1.1.529 / Omicron) :  Entire protein of Omicron BA.1; (1 aa difference to BA.2)
PepMix™ SARS-CoV-2 (VEMP B.1.1.529 / Omicron) : Entire protein of Omicron BA.1; (no difference)
PepMix™ SARS-CoV-2 (VME1 B.1.1.529 / Omicron) :  Entire protein of Omicron BA.1; (1 aa difference to BA.2)

Mutations
T0019I; L0024-; P0025-; P0026-; A0027S; G0142D; V0213G; G0339D; S0371F; S0373P; S0375F; T0376A; D0405N; R0408S; K0417N; N0440K; S0477N; T0478K; E0484A; Q0493R; Q0498R; N0501Y; Y0505H; D0614G; H0655Y; N0679K; P0681H; N0764K; D0796Y; Q0954H; N0969K

Omicron BA.4/5

Omicron BA.4/5

WHO Designation
Variant of Concern

Reference publication

Sequence used for library generation
EPI_ISL_12688263 (Gisaid accession ID)

JPT’s products

Mutations
T0019I, L0024-, P0025-, P0026-, A0027S, H0069-, V0070-, G0142D, V0213G, G0339D, S0371F, S0373P, S0375F, T0376A, D0405N, R0408S, K0417N, N0440K, L0452R, S0477N, T0478K, E0484A, F0486V, Q0498R, N0501Y, Y0505H, D0614G, H0655Y, N0679K, P0681H, N0764K, D0796Y, Q0954H, N0969K

Omicron BA.2.75

Omicron BA.2.75

WHO Designation
Variants under Monitoring

Sequence used for library generation
EPI_ISL_13392500  (Gisaid accession ID)

JPT’s products
PepMix SARS-CoV-2 (Spike BA.2.75 / Omicron) : Entire Spike Protein
PepMix SARS-CoV-2 (S-RBD BA.2.75 /  Omicron) : Spike Receptor Binding Domain

Mutations
T0019I, L0024-, P0025-, P0026-, A0027S, G0142D, K0147E, W0152R, F0157L, I0210V, V0213G, G0257S, G0339H, S0371F, S0373P, S0375F, T0376A, D0405N, R0408S, K0417N, N0440K, G0446S, N0460K, S0477N, T0478K, E0484A, Q0498R, N0501Y, Y0505H, D0614G, H0655Y, N0679K, P0681H, N0764K, D0796Y, Q0954H, N0969K

Omicron BA.2.75.2

Omicron BA.2.75.2

WHO Designation
Variants under Monitoring

Sequence used for library generation
EPI_ISL_15104931  (Gisaid accession ID)

JPT’s products
PepMix SARS-CoV-2 (Spike BA.2.75.2 / Omicron) : Entire Spike Protein
PepMix SARS-CoV-2 (S-RBD BA.2.75.2 /  Omicron) : Spike Receptor Binding Domain

Mutations
T0019I, L0024-, P0025-, P0026-, A0027S, G0142D, K0147E, W0152R, F0157L, I0210V, V0213G, G0257S, G0339H, R0346T, S0371F, S0373P, S0375F, T0376A, D0405N, R0408S, K0417N, N0440K, G0446S, N0460K, S0477N, T0478K, E0484A, F0486S, Q0498R, N0501Y, Y0505H, D0614G, H0655Y, N0679K, P0681H, N0764K, D0796Y, Q0954H, N0969K, D1199N

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Omicron BF.7

Omicron BF.7

WHO Designation
Variants under Monitoring

Sequence used for library generation
EPI_ISL_13183136  (Gisaid accession ID)

JPT’s products
PepMix SARS-CoV-2 (Spike BF.7 / Omicron) : Entire Spike Protein
PepMix SARS-CoV-2 (S-RBD BF.7 /  Omicron) : Spike Receptor Binding Domain

Mutations
T0019I, L0024-, P0025-, P0026-, A0027S, H0069-, V0070-, G0142D, V0213G, G0339D, R0346T, S0371F, S0373P, S0375F, T0376A, D0405N, R0408S, K0417N, N0440K, L0452R, S0477N, T0478K, E0484A, F0486V, Q0498R, N0501Y, Y0505H, D0614G, H0655Y, N0679K, P0681H, N0764K, D0796Y, Q0954H, N0969K

Omicron BQ.1.1

Omicron BQ.1.1

WHO Designation
Variants under Monitoring

Sequence used for library generation
EPI_ISL_14818139  (Gisaid accession ID)

JPT’s products
PepMix SARS-CoV-2 (Spike BQ.1.1/ Omicron) : Entire Spike Protein
PepMix SARS-CoV-2 (S-RBD BQ.1.1 /  Omicron) : Spike Receptor Binding Domain

Mutations
T0019I, L0024-, P0025-, P0026-, A0027S, H0069-, V0070-, G0142D, V0213G, G0339D, R0346T, S0371F, S0373P, S0375F, T0376A, D0405N, R0408S, K0417N, N0440K, K0444T, L0452R, N0460K, S0477N, T0478K, E0484A, F0486V, Q0498R, N0501Y, Y0505H, D0614G, H0655Y, N0679K, P0681H, N0764K, D0796Y, Q0954H, N0969K

Omicron XBB.1.5

Omicron XBB.1.5

WHO Designation
Variants under Monitoring


Sequence used for library generation
EPI_ISL_15687648  (Gisaid accession ID)

JPT’s products
PepMix SARS-CoV-2 (Spike XBB.1.5/ Omicron) : Entire Spike Protein
PepMix SARS-CoV-2 (S-RBD XBB.1.5 /  Omicron) : Spike Receptor Binding Domain

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Peptide Tools to Study SARS-CoV-2

Cellular Immunity

-> PepMix™ Peptide Pools
  • Antigen-specific T-cell stimulation
  • Cellular immune monitoring
  • Vaccine target discovery
  • Blood test development
  • Cross reactivity testing (SARS-CoV-2 vs. SARS, MERS, HCoV 229E, OC43…)
  • Cell therapy development
  • Efficient epitope mapping and identification
  • Matrix Pools and individual peptides spanning a whole antigen in one set
  • Minimal sample amount required
  • Antigen specific T-cell stimulation in T-cell assays (i.e. ELISpot, ICS)
  • Immune monitoring
  • Proliferation assays
  • T-cell expansion

Humoral Immunity

-> PepStar™ Peptide Microarrays
  • Humoral immune monitoring
  • Antibody epitope discovery
  • Cross reactivity testing (SARS-CoV-2 vs. SARS, MERS, HCoV 229E, OC43…)
  • Seromarker discovery
PepStar™ Antigen Collection Pan-Coronavirus
for cross reactivity testing with SARS-CoV-2 vs. SARS, MERS, HCoV 229E, OC43…)
PepStar™ Peptide Microarrays
for individual SARS-CoV-2 and SARS-CoV antigens
Tailored PepStar™ Peptide Microarrays
You define content and layout, we provide economic and fast production in our regulated clean-room environment. We also offer our assay and analysis service using your samples with your tailored peptide microarray.

  • Thousands of peptides spanning the entire SARS-CoV-2 genome using smallest sample volumes
  • Incubation using smallest sample volumes
  • Study of antibody cross-reactivities between SARS-CoV-2 and other corona viruses
  • Verification of peptide binders with a large numbers of samples
  • Transfer of results to ELISA platform for rapid test development
  • Peptide ELISA development and service using SARS-CoV-2 peptides or a combination with other corona viruses
  • ELISA-based validation service of peptide binders identified by using JPT’s peptide microarray platform
  • Collaborative ELISA test development

Clinical Immune Monitoring & Cell Therapy

-> Clinical Grade Peptides & PepMix™ Peptide Pools
  • High quality chemically synthesized antigen source for vaccine trial monitoring
  • Ancillary reagents for cellular therapy development
  • Full analytical coverage, stability testing, batch documentation and more

Proteomics

-> SpikeMix™ SARS-CoV-2
  • Identify SARS CoV-2 antigens from biological samples
  • Mass spectrometry based assays (MRM)
  • Screen 23 proteotypic peptides from SARS-CoV-2
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References

References

      • SARS-CoV-2 Spike-specific IFN-gamma T-cell Response After COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant
        Imhof et al., Infectious Disease (2022)
      • Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19
        Epis et al., Pharmacological Research (2022) - PMID: 36336215
      • Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19
        Kirchner et al., PLoS One (2022) - PMID: 36322587
      • Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant Viruses
        Levy et al., Vaccines (2022) - PMID: 34650130
      • Immunization with 674e685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice
        Lykhmus et al., Biochemical and Biophysical Research Communications (2022)
      • Treatment of Long COVID with nirmatrelvir/ritonavir and tocilizumab in a patient with rheumatoid arthritis and SARS-CoV-2 antigen persistence: a case report
        Visvabharathy et al., Research Square (2022) 
      • SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod
        Meyer-Arndt et al., J Neurol Neuroscurg Psychiatry (2022) - PMID: 35835468
      • A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2
        Ilinykh et al., Vaccines (2022) 
      • High‑resolution analysis of long‑term serum antibodies in humans following convalescence of SARS‑CoV‑2 infection
        Facciuolo et al., Scientific Reports (2022)
      • SARS-CoV-2 mRNA vaccination fails to elicit humoral and cellular immune responses in multiple sclerosis patients receiving fingolimod
        Meyer-Arndt et al., MedRxiv (2022)
        Products used: PepStar SARS-CoV-2 Spike Glycoprotein Variant Collection (incl. Omicron)
      • Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination
        Sistere-Oro et al., Frontiers in Immunology (2022) 
      • DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model
        Compagnone et al., Vaccines (2022) - PMID: 35893826 
      • SARS-CoV-2 Vaccine-Induced Antibody and T-Cell Response in SARS-CoV-1 Survivors
        Duan et al., Cell Reports (2022) 
      • The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and qualityunder TNFα blockade
        Geisen et al., Journal of Medical Virology (2022) - PMID: 35945627
      • Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses
        Padula et al., Vaccine: X (2022) - PMID: 35936992
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein SU1 & SU2) 
      • Analysis of the Specific Immune Response after the Third Dose of mRNA COVID-19 Vaccines in Organ Transplant Recipients: Possible Spike-S1 Reactive IgA Signature in Protection from SARS-CoV-2 Infection
        Miele et al., Microorganisms (2022)
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein SU1 & SU2) & SARS-CoV-2 NCAP 
      • mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
        Nanishi et al., Communications Biology (2022) 
      • SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype
        Terahara et al., iScience (2022) - PMID: 35992306
      • SARS‑CoV‑2‑reactive IFN‑γ‑producing CD4+ and CD8+T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID‑19 patients
         Olea et al., Scientific Reports (2022) - PMID: 35995830
      • Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response
        Stort et al., Oncoimmunology (2022)
         Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Humoral and cellular responses to mRNA-based COVID-19 booster vaccinations in patients with solid neoplasms under active treatment
        Su et al., ESMO Open (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Protective Immunity of COVID-19 Vaccination with ChAdOx1 nCoV-19 Following Previous SARS-CoV-2 Infection: A Humoral and Cellular Investigation
        Azamor et al., Viruses (2022) - PMID: 36146723
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Antibody and T-cellular response to COVID-19 booster vaccine in SARS-CoV-1 survivors
        Lu et al., Clinical Immunology (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein)
      • Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population
        Sarker et al., Vaccines (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Comparison between enzyme‐linked immunospot assay and intracellular cytokine flow cytometry assays for the evaluation of T cell response to SARS‐CoV‐2 after symptomatic COVID‐19
        Villemonteix et al., Immunity, Inflammation and Disease (2022)
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (NCAP) 
      • Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models
        Hajnik et al., Science Translational medicine (2022) - PMID: 36103514
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • A Recombinant VSV-Based Bivalent Vaccine Effectively Protects against Both SARS-CoV-2 and Influenza A Virus Infection
        Ao et al., Journal of Virology (2022) - PMID: 36069551
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein SUB1) 
      • SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN, induces robust humoral and cellular immunity in mice and non-human primates
        Alimohammadi et al., Vaccines (2022) - PMID: 36056015
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein)
      • Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3
        Swaminathan et al., Nature Communications
        Products used: PepMix SARS-CoV-2 (NCAP), SARS-CoV-2 (NS6), SARS-CoV-2 (NS7A), SARS-CoV-2 (NS7B), SARS-CoV-2 (NS8), SARS-CoV-2 (ORF9B), SARS-CoV-2 (ORF10), SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (VEMP), SARS-CoV-2 (VME1), SARS-CoV-2 (Y14) 
      • Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection
        Khatamzas et al., Nature Communication (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Evidence of premature lymphocyte aging in people with low anti-spike antibody levels after BNT162b2 vaccination
        Huang et al., iScience (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein)
      • NVX-CoV2373-induced cellular and humoral immunity towards parental SARS-CoV-2 and VOCs compared to BNT162b2 and mRNA-1273-regimens
        Hielscher et al., Journal of Clinical Virology (2022) - PMID: 36279695
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • Immune Response after the Fourth Dose of SARS-CoV-2 mRNA Vaccine Compared to Natural Infection in Three Doses’ Vaccinated Solid Organ Transplant Recipients
        Busà et al., Vaccines (2022) - PMID: 36298854
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (NCAP) and CEFX Ultra SuperStim Pool 
      • Proinflammatory Innate Cytokines and Distinct Metabolomic Signatures Shape the T Cell Response in Active COVID-19
        Binayke et al., Vaccines (2022) - PMID: 36298628
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2) 
      • Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose
        Belik et al., Research Square (2022)
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (Spike B.1.1.529 / BA.1 / Omicron), and SARS-CoV-2 (Spike B.1.1.529 / BA.2 / Omicron)
      • Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 Vaccine
        Lam et al., ACS Nano (2022)
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2) 
      • Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
        Palacios-Pedrero et al., Nature Aging (2022)
        Product used: PepMix SARS-CoV-2 (NCAP)
      • Humoral and Cellular Responses to a Delayed Fourth SARS-CoV-2 mRNA-Based Vaccine in Weak Responders to 3 Doses Kidney Transplant Recipients
        Del Bello et al., Vaccines (2022) - PMID: 36146517
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2) 
      • A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses
        Lenart et al., Molecular Therapy (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • A Tale Of T ale Of Two Transgenes: Aa ansgenes: Aav-Dystr v-Dystrophin And Aa ophin And Aav-Spike Reveal Common Themes For Gene Therapy And Vaccines
        Greer, Dissertation (2022)
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein) and SARS-CoV-2 (Spike B.1.1.7 / Alpha) 
      • Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern
        Akache et al., Vaccines (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein)
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        Tang et al., Science Immunology (2022) - PMID: 35857583
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        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
      • A novel SARS-CoV-2 subunit vaccine engineered on an immune-activating platform technology
        Quinlan et al., Human Vaccines & Immunotherapeutics (2022) - PMID: 35801956
        Product used: PepMix SARS-CoV-2 (Spike-RBD) 
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        Robbins et al., The Lancet (2022)
        Product used: PepMix SARS-CoV-2 (Spike Glycoprotein) 
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        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein SU1 & SU2), SARS-CoV-2 (Spike B.1.617/Delta),  SARS-CoV-2 (Spike B.1.1.529 / BA.1 / Omicron)
      • Long-Lived Immunity in SARS-CoV-2-Recovered Children and Its Neutralizing Capacity Against Omicron
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        Product used: PepMix SARS-CoV-2 (VME1), SARS-CoV-2 (VEMP), SARS-CoV-2 (NCAP),  SARS-CoV-2 (Spike B.1.1.529 / BA.1 / Omicron) 
      • T-cell proliferation assay for the detection of SARS-CoV-2-specific T-cells
        Chu et al., Clinical Chimica Acta (2022) - PMID: 35690083
        Products used: PepMix SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (NCAP), SARS-CoV-2 (VME1) 
      • A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection
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        Kaewborisuth et al., Vaccines (2022) 
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        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2)
      • Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide
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        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2)
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        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2)
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      • Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters
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        Product used: PepMix™ SARS-CoV (Spike Glycoprotein)
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        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2)
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        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein), SARS-CoV-2 (NCAP), HCoV-OC43 (Spike Glycoprotein)
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        Product used: PepMix™ SARS-CoV-2 (Spike Glycoprotein)
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        Dowling et al., Research Square (2022)
        Products used: PepMix™ SARS-CoV-2 (Spike Glycoprotein) & SARS-CoV-2 (S-RBD B.1.1.529 / Omicron)
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