Peptide Tools to Study Influenza Virus
About the Influenza Virus
Influenza viruses belong to the orthomyxoviridae family. These are enveloped viruses with a segmented, negative-sense, single- stranded RNA genome. Only orthomyxoviridae Influenza type A and B cause disease in humans. Their main antigenic determinants are the two transmembrane proteins hemagglutinin (‘H’ or ‘HA’) and neuraminidase (‘N’ or ‘NA’).
The combinations of specific variants of the H (H1-H18) and N (N1-N11) proteins are used to classify Influenza A viruses into subtypes. The standard WHO nomenclature for a given human influenza virus comprises the genus (‘A’), the geographical site where they were first identified (e.g. Hong Kong), a serial number and the identification year (e.g. 1/1968), and finally the H and N variants.
Besides Influenza A & B (or C) affecting humans, Influenza subtypes are also commonly found in other reservoirs. Examples include H5N1 for avian Influenza A or H1N1 which is associated with the 2009 swine flu pandemic.
JPT offers a range of highly relevant Influenza virus-specific antigen peptides, PepMix™ peptide pools and PepStar™ peptide microarrays. Some of these products are listed in the following table, listing egg-based, cell culture-, or recombinant-based vaccines that have been developed in the past years in the northern and southern hemisphere:
| Northern Hemisphere | Egg-based Vaccines | Cell culture- or recombinant-based vaccines |
| 2023-2024 |
|
|
| 2022-2023 | ||
| 2021-2022 |
|
|
| 2020-2021 |
|
|
| 2019-2020 |
|
| Southern Hemisphere | Egg-based Vaccines | Cell culture- or recombinant-based vaccines |
| 2024 |
|
|
| 2023 |
|
|
| 2022 | ||
| 2021 |
|
|
| 2020 |
|
JPT's Influenza Peptide Formats
Cellular Immune Response
PepMix Peptide Pool
- Antigen specific stimulation of T-cells
- Immune monitoring of high-risk patients
- Identification of immunodominant antigens
- Validating clinical T-cell assays
- covers strains from Influenza A such as: H1N1 (Brisbane), H1N1 (California), H1N1 (Puerto Rico), H2N2 (AnnArbor), H3N2 (HongKong), H5N1 (Indonesia), H5N1 (Turkey) and H10N8 (Jiangxi)
- covers strains from Influenza B such as: H0N0 (Phuket) and H0N0 (Austria)
- PepMix Ultra Pools reflect sequence variety through specialist and selected peptide sequences
- T-cell assays
- High-throughput T-cell epitope discovery
- Monitoring of cellular immune response
JPT also offers custom-designed PepMix™ Peptide Pools for your specific needs!
Humoral Immune Response
PepStar™ Peptide Microarray
- Immune monitoring of humoral responses
- Profiling of Influenza-specific samples or antibodies
- Detection of epitopes and epitope spreading
JPT also offers custom designed tailored PepStar™ Peptide Microarrays
You define content and layout, we provide economic and fast production in our regulated clean-room environment.
Ship your samples and obtain high-quality results analysed by experts! We also offer a complete assay and analysis service for your samples using your own, custom-designed peptide microarray.
Clinical Peptides
JPT’s clinical peptide product lines, ‘Clinical Grade’ and ‘ISO Plus’, are produced in a tightly regulated production environment for the stringent product requirements of immunotherapy, vaccine, and drug development. Our products have been approved for clinical use with respect to specific immunotherapeutic applications.
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