Peptide Tools to Study Influenza Virus

About the Influenza Virus

Influenza viruses belong to the orthomyxoviridae family. These are enveloped viruses with a segmented, negative-sense, single- stranded RNA genome. Only orthomyxoviridae Influenza type A and B cause disease in humans. Their main antigenic determinants are the two transmembrane proteins hemagglutinin (‘H’ or ‘HA’) and neuraminidase (‘N’ or ‘NA’).
The combinations of specific variants of the H (H1-H18) and N (N1-N11) proteins are used to classify Influenza A viruses into subtypes. The standard WHO nomenclature for a given human influenza virus comprises the genus (‘A’), the geographical site where they were first identified (e.g. Hong Kong), a serial number and the identification year (e.g. 1/1968), and finally the H and N variants.

JPT offers a range of highly relevant Influenza virus-specific antigen peptides, PepMix™ peptide pools and PepStar™ peptide microarrays. Some of these products are listed in the following table, listing egg-based, cell culture-, or recombinant-based vaccines that have been developed in the past years in the northern and southern hemisphere: 

Northern Hemisphere
Egg-based Vaccines
Cell culture- or recombinant-based vaccines

Southern Hemisphere
Egg-based Vaccines
Cell culture- or recombinant-based vaccines

JPT's Influenza Peptide Formats

Cellular Immune Response

PepMix Peptide Pool 
  • Antigen specific stimulation of T-cells
  • Immune monitoring of high-risk patients
  • Identification of immunodominant antigens
  • Validating clinical T-cell assays

  • covers strains from Influenza A such as: H1N1 (Brisbane), H1N1 (California), H1N1 (Puerto Rico), H2N2 (AnnArbor), H3N2 (HongKong), H5N1 (Indonesia), H5N1 (Turkey) and H10N8 (Jiangxi)
  • covers strains from Influenza B such as: H0N0 (Phuket) and H0N0 (Austria)
  • PepMix Ultra Pools reflect sequence variety through specialist and selected peptide sequences

  • T-cell assays
  • High-throughput T-cell epitope discovery
  • Monitoring of cellular immune response

JPT also offers custom-designed PepMix™ Peptide Pools for your specific needs!

Humoral Immune Response

PepStar™ Peptide Microarray
  • Immune monitoring of humoral responses
  • Profiling of Influenza-specific samples or antibodies
  • Detection of epitopes and epitope spreading

You define content and layout, we provide economic and fast production in our regulated clean-room environment.
Ship your samples and obtain high-quality results analysed by experts! We also offer a complete assay and analysis service for your samples using your own, custom-designed peptide microarray.

Clinical Peptides

JPT’s clinical peptide product lines, ‘Clinical Grade’ and ‘ISO Plus’, are produced in a tightly regulated production environment according to an enhanced ISO 9001:2015 quality management system for the stringent product requirements of immunotherapy, vaccine, and drug development. Our products have been approved for clinical use with respect to specific immunotherapeutic applications. 


References 2023

References 2023

    References Archive

    References Archive

    • Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines
      Aydillo et al., Emerging Microbes & Infections (2023) - PMID: 38054302
      Products used: PepMix Influenza A (HA/H1N1/Victoria/2019)Influenza A (HA/H3N2/Darwin/2021)custom PepMix Influenza B Nucleoprotein
    • Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19
      Kirchner et al., PLoS One (2022) - PMID: 36322587
      Products used: PepMix Pan-SARS-CoV-2 Select, SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2), SARS-CoV-2 (NCAP), SARS-CoV-2 (VEMP), HCoV-229E (Spike Glycoprotein), HCoV-OC43 (Spike Glycoprotein), HRSVB (Nucleocapsid Protein N), PepMix Influenza A (M1) Ultra
    • Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection
      Van den Berg, Journal of Immunology (2022) - PMID: 34025665
    • Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients
      Oja et al., BioRxiv (2022)
    • A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2
      Ilinykh et al., Vaccines (2022) - PMID: 35468973
    • Transcriptional Programs of Neoantigen-Specific TIL in Anti-PD-1-Treated Lung Cancers
      Caushi et al., Nature (2021) - PMID: 34290408
    • M2-Deficient Single-Replication Influenza Vaccine–Induced Immune Responses Associated With Protection Against Human Challenge With Highly Drifted H3N2 Influenza Strain
      Eiden et al., Journal of Infectious Diseases (2021) - PMID: 34323977
    • A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse Model
      Koonpaew et al., Vaccines (2021) - PMID: 34451975
    Application Notes

    Application Notes


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