Peptide Tools to Study Autoimmune Diseases
About Autoimmune Diseases
- Abnormal immune responses directed towards the body's own proteins (self-antigens)
- Leads to tissue damage
- 80 types of autoimmune diseases known such as systemic lupus erythematosus, celiac disease, diabetes mellitus type 1, Graves' disease, multiple sclerosis and rheumatoid arthritis
- Causes are mostly unknown, diagnosis can be difficult
- Treatments can improve symptoms
- Autoimmune diseases cannot be cured
Diabetes & Obesity
One of the most common autoimmune diasese is Diabetes. Diabetes is an endocrine disease leading to very high blood sugar levels caused by either the pancreas not producing enough insulin (diabetes type 1 or insulin-dependent diabetes mellitus), or the cells of the body becoming insulin resistant (diabetes type 2 or insulin-dependent diabetes mellitus). Peptides can contribute:
- Use of C-peptides in diagnostics
- Insulin replacement therapies
- Peptide-based treatment like semaglutide or GLP-1 receptor agonists
Target & Epitope Discovery
Target and epitope discovery represent major challenges to enable early diagnosis and the development of suitable treatment strategies. JPT possesses a variety of unique high-throughput peptide-based technologies enabling deep discovery of relevant targets as well as systematic discovery of B- and T-cell epitopes.
In addition, our ultra-fast and cost efficient peptide synthesis strategies together with sophisticated bioinformatics approaches enable sequence diversity considerations (splice variants, mutations etc.) and post-translational modifications that have not previously been addressed from proteome-spanning perspectives.
JPT's peptide tools to study autoimmune diseases
JPT's Autoimmune Peptide Formats