SARS-CoV-2 B Cell Epitopes

Humoral immunity to SARS-CoV-2 is a crucial factor of immune protection.

Peptide microarray based analysis of antibody responses to SARS-CoV-2 was performed in collaboration with University of Potsdam, KH Labor GmbH, and several local partners. Screening for antibodies was performed against the entire SARS-CoV-2 proteome as well as selected proteins of HCoV strains SARS, MERS, OC43 and 229E. While widespread cross-reactivity against HCoVs was revealed, several unique epitopes were identified. These may serve as capture antigens for future, highly COVID-19-specific diagnostic antibody tests.

References

Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test development
Holenya et al., Eur. J. Immunol. (2021) - PMID: 33772767

Technologies

Partners

Institute for Molecular Diagnostics and Bioanalysis-IMDB GmbH, Hennigsdorf, Germany
KH Labor GmbH, Bernburg, Germany
Medical Faculty, Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
Institute for Biochemistry and Biology, University of Potsdam, Potsdam, Germany
in.vent GmbH, Hennigsdorf, Germany