Peptide Tools to Study Monkeypox Virus
About Monkeypox Virus
Monkeypox virus (Orthopoxvirus simiae) belongs to the family of Poxviridae, which can cause a zoonotic disease commonly referred to Monkeypox. 83 species belong to this family of these double- stranded DNA viruses including the orthopox subfamily with
- Smallpox virus (Variola)
- Vaccinia virus
- Cowpox virus
- Rabbitpox virus
- Monkeypox virus
Of note, the common chickenpox virus (varicella zoster virus) is a herpesvirus and does not belong to the poxviruses.
Cross-immunity within the Orthopox subfamily
Vaccination against smallpox seems to be quite effective (approx. 85%) in preventing monkeypox as
shown in several observational studies.
This could be because many of the viral proteins show great levels of homology within different
orthopoxviridae as shown in belows table.
Uniprot ID | Protein name | PepMix Product Code | Homology (%)* |
---|---|---|---|
O57206 | IMV heparin binding surface protein (MVA093L) | PM-MVA-093L |
96.6 |
O57211 | Cell surface-binding protein (MVA105L) | PM-MVA-105L | 97 |
O57196 | Putative 49.8k protein (MVA 074R) | PM-MVA-074R |
98.8 |
P68598 | Host range protein 2 (MVA018L) | PM-MVA-018L |
99.3 |
O57223 | Major core protein P4a (MVA 121L) | PM-MVA-121L |
98.3 |
P07614 | Protein L3 | PM-VACV-L3L |
97.4 |
O57265 | Putative 21.7k protein (MVA189R) | PM-MVA-189R |
63.5 |
* defined as the percentage of residues with a positive BLOSUM50 score (gap is score -5) in a comparison of aligned sequences.
Table 1: Homology of different vaccinia antigens that are represented in JPT’s proprietary PepMix
peptide pools with the respective monkeypox antigens.

JPT's Peptide Tools to Study Monkeypox Virus
Cellular Immune Response Profiling
- efficient for antigen-specific stimulation in T cell assays such as ELISPOT and flow cytometry
- highest quality and batch-to-batch consistency, whole production ISO 9001 certified
- PepMix Pan-Poxviridae Select: 127 immunodominant peptide epitopes combining all major antigens of Monkeypox virus (MPXV), Smallpox virus (VARV), Vaccinia virus (VACV), Variola virus (VARV)
- PepMix peptide pools for various Vaccinia virus antigens: e.g. Protein L3, IMV heparin binding surface protein, cell surface-binding protein and more
- Custom PepMix™ Peptide Pools tailored for your specific needs!
- T-cell assays
- High-throughput T-cell epitope discovery
- Monitoring of cellular immune response
Humoral Immune Response Profiling
- Immune monitoring of humoral responses
- Profiling of monkeypox-specific samples or antibodies
- Evaluation of co-infection * Detection of epitopes and epitope spreading
- PepStar peptide microarrays for various Vaccinia virus antigens: e.g. Protein L3, IMV heparin binding surface protein, cell surface-binding protein and more
- Tailored PepStar™ Peptide Microarrays, you define content and layout
Peptide ELISA