Immune Monitoring

use of immune monitoring

Precise immune monitoring to evaluate responses and changes of the immune system prior or during therapy is critical in many areas of pre-clinical and clinical immunological research and development. The selection of an appropriate and reliable antigen source has a crucial impact on the success of such studies.

This is why Peptides are Better Antigens!

  • Peptides and pools mimic protein antigens or epitopes
  • Peptides can be synthesized with high purity, low bioburden and sterile
  • High batch-to-batch reproducibility
  • No antigen expression needed, avoiding bacterial contamination
  • ADCF policy applicable
Work with the Peptide Expert and take advantage of our unparalleled peptide quality & customer service, unique peptide formats for discovery, therapy, and immune monitoring and an optional personal consultation to help you with peptide specifications.

Cellular Immune Monitoring

Our peptide formats allow efficient profiling of antigen-specific cellular immune responses by cellular assays such as ELISPOT and Flow Cytometry. JPT's  unique peptide specifications

  • Avoid peptide cross-contamination
  • Inhibit false positive T-cell stimulation by synthetic by-products
  • Eliminate cell toxic by-products
  • Allow for peptide stability and peptide solubility evaluation
  • Are produced according to our ISO 9001 certified QMS 
  • Learn more about Peptide Quality & Purity

For critical clinical trial monitoring JPT maintains a specification called ISO PLUS that complies with relevant regulatory requirements on line clearance, quality oversight, batch documentation and more. The combination of our long-term peptide chemistry and bioinformatics knowledge with highest regulated quality standards enables efficient, high quality clinical profiling of cellular immune responses.

Have a look at our products for cellular immune monitoring products:

PepMix™ Peptide Pools

Our antigen spanning PepMixes™ are available in a large variety of more than 400 off-the-shelf peptide pools (e.g. SARS-CoV-2, EBV, HCMV, AdV, HPV antigens and many tumor associated antigens) or customized according to the specification of your application and antigens. 
Our control pools CEFX and CEF are the gold standard for any antigen-specific cellular assay. 

Check our PepMix™ Peptide Pools list, pricing and information!

Antigen Peptides

JPT offers specific peptide epitopes for stimulation of T cells in interferon gamma-releasing T cell assays such as ELISPOT.  Use antigen peptides for efficient immune monitoring, mapping of T cell epitopes or development of immunotherapies and vaccines.

Check our Antigen Peptides list, pricing and information!

T Cell Assay Service

We offer T cell assays such as ELISpot, ICS/flow cytometry and multimer staining as full service. Our dedicated S2 lab operates according to strict ISO 9001 regulations. Additionally, we can assist you with target selection, sequence analysis with bioinformatic assistance and with peptide library design. Our service includes peptide synthesis, peptide pooling, matrix pool design & plating and T cell assay execution.

Have a look at our T Cell Assay Services!

Clinical Peptides & Pools

JPT’s Clinical Grade and ISO Plus Peptides & PepMix™ Pools are produced in production environments regulated by an enhanced ISO 9001:2015 quality management system for the more stringent requirements of cell therapy and immune monitoring. 
The ISO PLUS specification was developed especially for clinical trial immune monitoring bridging the gap between standard RUO peptides, and high-prized GMP Peptides. They have been applied in various successful clinical applications. 


Humoral Immune Monitoring

Our proprietary peptide-based humoral immune monitoring technologies allow high resolution profiling of antibody related immune responses. Purified antibodies, patient sera and even whole blood can be used with our assay platforms targeting specific antigens, entire antigen families or selected epitopes and neo-epitopes. This allows effective B-cell epitope resolved elucidation of antibody responses in clinical studies as well as recognition of certain epitope patterns and epitope spreading. Additionally, we can address natural sequence diversity, mutations and post-translational modifications that occur in cancer cells and different types of viruses.

PepStar™ Peptide Microarrays

JPT offers PepStar™ peptide microarrays for profiling of patient samples or antibodies, detection of epitopes or neo-epitopes, vaccine target identification, and monitoring of epitope spreading. Peptide microarrays are reliable and efficient tools for screening assays such as the characterization of potential therapeutic antibodies, the identification of novel biomarkers, and the elucidation of protein-protein interactions.
PepStar peptide microarrays display overlapping peptide scans through antigens, or any other peptide sequences. You define content and layout and we provide your custom peptide micorarrays produced in our regulated clean-room environment. 
Or choose one of more than 200 off-the-shelf peptide microarrays display overlapping peptide scans through proteins or entire proteomes.

Check our PepStar™ Peptide Microarrays list, pricing and information!

Peptide ELISA

We offer customized peptide-coated ELISA plates (enzyme-linked immunosorbent assay). ELISA is a well-established sensitive immunological assay for proteins but it requires detailed experimental know-how is you want to use peptides. Peptide ELISA is used for mapping of epitopes and definition of protein interaction sites or as a validation assay to confirm results obtained with JPT’s peptide microarrays.

Please visit Peptide ELISA

PepSpots Peptide Arrays on Membrane

PepSpots are membrane-bound peptide arrays used for efficient and inexpensive antibody epitope mapping and protein-protein interaction studies. Peptides are synthesized by our proprietary SPOT technology directly on hydrophilic cellulose membranes, which minimize non-specific binding. Easy detection using standard ELISA protocols.

BioTides Biotinylated Peptides

BioTides can be used for any biomedical screening assay that requires immobilization onto streptavidin coated beads, membranes, glass slides or microtiter plates (e.g. Peptide ELISA). They are synthesized by JPT's proprietary SPOT synthesis technology providing fast access to large numbers of biotin peptides at unmatched pricing.

For further information and quote request visit BioTides

Neo-Epitopes & Immune Monitoring

Have a look at our solutions for the specific needs for Neo-Epitope Immune Monitoring during neo-epitope therapy.                                                                                                                                                                          

Check our list of products, click and go.

Get a quote