Neo-Epitope Prioritization

Neo-epitopes are important targets for individualized cancer immunotherapy. Recent advances in next generation sequencing and bioinformatic approaches to predict immunogenicity of neo-epitopes have improved target selection for therapy. However, in many cases only a fraction of predicted epitopes generate a specific T-cell response. Therefore, various assay techniques such as ELISpot, MHC-binding, or mass-spectrometry are being applied to confirm and prioritize neo-epitopes for individualized therapies. The ability to create meaningful and truly patient-individualized sets of neo-epitopes ultimately requires high-throughput formats and thus large numbers of small scale, high quality, and low cost peptides, delivered rapidly.

Benefits of working with JPT
  • Proprietary technology for fast and low-cost access to large numbers of peptides
  • Light and heavy labelled peptides available
  • High quality standards ISO 9001:2015
  • Long-term knowledge in peptide synthesis and immunology
  • Prioritization for subsequent cell therapy & vaccine development

PepTrack™ Peptide Libraries: FastTrack & FastTrack PLUS

FastTrack and FastTrack PLUS offer low-cost access to thousands of neo-epitope peptides within very short time periods enabling ultra-fast prioritization of neo-epitopes by means of functional, binding or mass spectrometric assays.

SpotMix Antigen Discovery Pools

SpotMix Antigen Discovery Pools consist of overlapping & pooled peptides or pooled neo-epitope peptides synthesized by our proprietary ultra-high throughput SPOT technology. We provide SpotMix Pools quickly and at low cost. They are optimal for antigen target discovery, T-cell epitope discovery, and epitope based immune monitoring.

NeoSpikeMix for Immunopeptidomics

Immunopeptidomics applies mass spectrometry to discover, verify, and prioritize neo-epitopes. In contrast to other assays, it can be largely paralleled and analyzes many peptides at the same time. However, challenges such as limited sensitivity and specificity still exist. Peptides quickly synthesized at low costs have proven to be excellent reference standards for HLA peptides. NeoSpikeMixes are customized small scale peptide libraries to be used as references for HLA peptides by mass spectrometry. They provide fast and cheap access to reference peptides to increase accuracy of neo-epitope identification.

PepStar™ Peptide Microarrays

JPT offers customized peptide microarrays for detection of neo-epitopes on the humoral immune response level. Peptide microarrays display overlapping peptide scans through antigens, or any other peptide sequences. You define the content and format and we provide economic and fast production in our regulated clean-room environment.
use of neo epitope prioritization

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