Peptide Tools to Study Coronaviruses
- Severe acute respiratory syndrome coronavirus (SARS-CoV)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Middle East respiratory syndrome-related coronavirus (MERS)
- Common cold coronaviruses HCoV 229E, OC43, HKU1 and NL63
- Various animal coronaviruses
Coronaviruses have a positive-sense single-stranded RNA genome and characteristic spikes on their surface, which create an image reminding of the solar corona. The spikes are composed of Spike proteins (S protein) which contain two subunits. Subunit S1 forms the spike head with the receptor binding domain (RBD). Subunit S2 forms the stem and enables fusion with the host cell. S1 proteins are the most variable components of the virus as they are responsible for host cell specificity. Spike protein, membrane protein (M) and envelope protein (E) are anchored in the viral envelope, a lipid bilayer.
JPT is an expert for manufacturing a wide variety of synthetic peptide formats for research and clinical applications in the development of immunotherapy and vaccines and immune monitoring. Our researchers constantly develop new products for well-known infectious diseases such as HIV, TB or HBV as well as newly emerging diseases such as MERS, SARS and COVID-19.
JPT's Peptide Tools to study coronaviruses
JPT's Coronavirus Peptide Formats
Cellular Immunity
- Antigen-specific T-cell stimulation
- Cellular immune monitoring
- Vaccine target discovery
- Blood test development
- Cross reactivity testing between viruses
- Cell therapy development
- Efficient epitope mapping and identification
- Matrix Pools and individual peptides spanning a whole antigen in one set
- Minimal sample amount required
Humoral Immunity
- Humoral immune monitoring
- Antibody epitope discovery
- Serological test development discovery
- Cross-reactivity testing (SARS-CoV-2 vs. SARS, MERS, HCoV 229E, OC43…)
- Screening individual antigens of SARS-CoV-2 and SARS
- PepStar™ Pan Coronavirus
- Thousands of peptides spanning entire antigens or genomes
- Incubation using smallest sample volumes
- Study of antibody cross-reactivities between SARS-CoV-2 and other corona viruses
- Verification of peptide binders with a large numbers of samples
- Transfer of results to ELISA platform for rapid test development
- Peptide ELISA development and service using virus antigen peptides
- ELISA-based validation service of peptide binders identified by using JPT’s peptide microarray platform
- Collaborative ELISA test development
Clinical Trial Immune Monitoring & Cell Therapy
- High quality chemically synthesized antigen source for vaccine trial monitoring
- Ancillary reagents for cellular therapy development
- Full analytical coverage, stability testing, batch documentation and more
Proteomics
- Peptide pool of stable isotope labeled peptides from relevant SARS CoV-2 antigens
- Identify and quantify virus antigens from biological samples using mass spectrometry based assays (MRM)
- Screen 23 ready-made proteotypic peptides from SARS-CoV-2
- Or order your custom SpikeMix™