Peptide Tools to Study HCMV
About Human Cytomegalovirus
HCMV or HHV-5 belongs to the family of Herpesviridae and is known to establish latency in leukocytes. At least 40% of adults worldwide have been exposed to HCMV. Whereas it is typically unnoticed in healthy individuals, HCMV infection can become life-threatening for high-risk groups such as pre- and postnatal infants or immunocompromised individuals e.g HIV-infected patients and organ transplant recipients. Therefore, these individuals require regular immune monitoring to detect acute HCMV infections.
Studies in humans and animal models have demonstrated a critical role for both CD4+ and CD8+ T-cell immunity in limiting viral replication and preventing the clinical manifestations of progressive infection. Many studies focus on pp65 for general immune monitoring. However, other antigens can be immune relevant and are often investigated in HCMV vaccine development. Furthermore, HCMV specific humoral immune responses have been reported and correlated to viral load.
JPT's Peptide Tools to Study HCMV
JPT's HCMV Peptide Formats
Cellular Immune Response Profiling
PepMix™ Peptide Pools
- Immune monitoring of high-risk patients
- Qualification of immunodominant antigens
- Validating clinical T-cell assays
- PepMix™ Collection HCMV: 19 different antigens
- HCMV PepMix™ Peptide Pools: Individual peptide pools for IE-1, IE-2, pp65, UL28, UL32, UL36, UL40, UL48, UL55, UL82, UL86, UL94, UL99, UL103, UL151, UL153, US3, US24, US29 and US32
- Custom PepMix™ Peptide Pools tailored for your specific needs!
- T-cell assays
- High-throughput T-cell epitope discovery
- Monitoring of cellular immune response
- Clinical trials
Humoral Immune Response Profiling
- Immune monitoring of humoral responses
- Profiling of HCMV specific samples or antibodies
- Evaluation of co-infection
- Detection of epitopes and epitope spreading
- PepStar Microarrays for IE-1, IE-2, pp65, UL32, UL40, UL86, UL99, and UL153
- PepStar Antigen Collection HCMV with all of the above on one microarray
- Custom PepStar™ Peptide Microarrays, you define content and layout