SARS-CoV-2 Antigen Peptide Spike Fusion (SFIEDLLFNKVTLAD)

SARS-CoV-2 Antigen Peptide Spike Fusion (SFIEDLLFNKVTLAD) - Fusion Peptide for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays.

SARS-CoV-2 Antigen Peptide Spike Fusion (SFIEDLLFNKVTLAD) - Specifications

Background: A 15 amino acid stretch of the SARS-CoV-2 spike glycoprotein was recently shown to induce strong T-cell reactivity in individuals following SARS-CoV-2 vaccination and infection, and responses were also found in individuals with prior exposure to other human coronaviruses (Loyal et al., Science 2021). The amino acid stretch (named iCope) was independently predicted as a region of major antigenic potential in silico (Ong et al. Comp. Struct. Biotechnol. J. 2021).

The respective peptide sequence is located in the spike glycopeptide fusion domain and is likely to give rise to one or more universal immunodominant coronavirus-specific peptide epitopes across a range of presenting HLA-alleles.

Visit our webpage for more information on SARS-CoV-2, its mutations & variants and our corresponding products.

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JPT’s SARS-CoV-2 Antigen Peptides
Individual antigen peptides are derived from information on the human immune response towards SARS-virus, which is very similar to SARS-CoV-2. Sequences which are identical (28 peptides) or similar (13 peptides with one mutation, 7 with two and one with three) to experimentally confirmed SARS-epitopes are made available through our shop. These peptides can be used for antigen specific T-cell stimulation, T-cell assays or T-cell expansion. JPT Peptide Technologies has substantial, long-standing expertise in providing peptides, peptidomimetics, and proteins to the global scientific community. Our highly skilled and committed scientific staff ensures that the most appropriate methods and techniques are selected for every synthesis project. All our catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.

Benefits of JPT’s Antigen Peptides
- Whole production performed in a regulated European environment according to DIN EN ISO 9001:2015 & GCLP standards; audits welcome!
- Synthesis protocols designed to avoid toxic contaminants and side products
- Provision of freeze dried aliquots for enhanced stability
- Proven track record for applications in clinical studies
- Order the connected PepMix™ Peptide Pool and MHC Dextramer with your peptide as a set!