Custom Peptide Synthesis

At JPT, we pride ourselves on our extensive and long-standing expertise in custom peptide synthesis. Our commitment to providing the highest quality custom peptides, regardless of the complexity or number of the peptide sequences, sets us apart. Request a quote to receive a competitive custom peptide synthesis price. If you need a reliable and high-quality peptide synthesis service using regulated processes, look no further than JPT. Order custom peptides with your required specifications, modifications, quantity, and peptide format!

Why Choose JPT’s Custom Peptide Synthesis Service

With our 20 years of experience, we synthesize over 1 million peptides per year. Our custom peptide synthesis service boasts an exceptional success rate of over 99% thanks to our extensive expertise. We go the extra mile to tailor a peptide specification that perfectly fits your application, ensuring optimal results every time. Here are some of the key features of our service:

• Unparalleled capacities for custom peptide synthesis
• Quality management system certified to ISO 9001:2015 standards
• Clinical Peptides and Pools synthesis to meet various needs
• Dedicated peptide production labs for synthesis and purification
• State-of-the-art equipment and highly trained peptide synthesis staff
• Compliance with the highest environmental, health, and ethical standards
• Scientific customer support trained in peptide applications
• Assistance in selecting peptide specifications when ordering custom peptides with us
• Competitive custom peptide synthesis price

Quality Control in Custom Peptide Synthesis

Quality control is a cornerstone of our custom peptide synthesis process. After synthesis, each peptide undergoes routine analysis by LC-MS, MALDI-MS, or HPLC to confirm its identity and peptide purity. JPT provides a thorough analytical data sheet and corresponding raw data documentation with each custom peptide synthesis order. All documentation is meticulously double-checked and archived before leaving our facility. Our standard quality control includes LC-MS with ion trap, quadrupole, or TOF detection, MALDI-MS, or HPLC. We also offer a variety of optional Peptide Analysis Services, including Stability Testing, Peptide Content Determination, and Cell Toxicity Testing:

• AAA (amino acid analysis)
• Peptide sequence analysis (mass spectrometry)
• Residual solvent and water determination
• Solubility and stability testing
• Toxicity, sterility, endotoxin, and bioburden testing
• NMR (nuclear magnetic resonance)
• And many more!

Modifications and Labels for Custom Peptide Synthesis

JPT also excels in the design and production of custom peptides with various modifications, such as fluorescent labels, biotinylation, alkylation, glycosylation, phosphorylation, and more. These modifications can enhance the functionality and stability of peptides, making them suitable for a wide range of applications in research and medicine.

We offer an extensive range of peptide modifications, labels, and tags and are committed to synthesizing even the most challenging peptides. Our custom peptide synthesis options include:

• Unnatural & unusual amino acids
• Isotope-labeled peptides
• Macrocyclic peptides
• Post-translational modifications
• Fluorescent & FRET peptides
• Biotinylated & tagged peptides
• Long, cyclic, or dimeric peptides
• Various linkers, spacers, & PEGs
• Protein conjugates & immunogenic peptides
• Peptidomimetics
• Peptide pooling and library services

For detailed information on the custom peptide synthesis of modified peptides, please visit our Peptide Modifications & Specialty Peptides and Post-translational Modifications pages. Contact us or send us a quote request for modified custom peptide synthesis price.

Advantages of Custom Peptides over Whole Proteins

• High-batch-to-batch reproducibility
• Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation
• Extended shelf stability when stored lyophilized
• Modifications, labels, tags and cyclization can be added
• Custom peptide synthesis prices are much lower
• Equivalent or better stimulation of T-cell responses
• Improved responses in stored blood and PBM cells compared to whole proteins
• Peptides can mimic the behavior of a natural ligand
• Custom peptides can be precisely targeted
• Order custom peptides with consistent quality

The Science Behind Custom Peptide Synthesis

Custom peptide synthesis involves the creation of peptides by sequentially adding amino acids to a growing chain. This process can be performed using either solid-phase peptide synthesis (SPPS) or liquid-phase peptide synthesis (LPPS). SPPS, developed by Robert Bruce Merrifield, is the most commonly used method due to its efficiency and versatility. JPT adds an additional step, called capping, after each amino acid coupling. Capping prevents the formation of deletion sequences, which can lead to false positive results. For more information, please watch our capping video:

In addition to classic solid phase custom peptide synthesis, JPT uses SPOT synthesis, which allows the synthesis of hundreds of micro scale peptides in parallel. The resulting high-throughput peptides are fast and have the lowest custom peptide synthesis prices on the market.

Request a custom peptide synthesis quote

At JPT, we are committed to supporting your research and clinical needs with our custom peptide synthesis services. Our team of experts is ready to assist you with any inquiries or orders. Contact us today to find out how our custom peptide synthesis can enhance your research projects and clinical applications.