Isotope Labeled Peptides: Precision Tools for Research
Stable isotope labeled peptides are synthesized by substituting specific atoms in natural amino acids with heavy isotopes, such as replacing 12C with 13C, 14N with 15N, or 1H with 2H (deuterium). These modifications result in isotope labeled compounds that retain the same physiochemical properties and chemical reactivity as their non-labeled counterparts. This makes them indispensable in a wide array of scientific applications, including mass spectrometry, NMR studies, and pharmacokinetic analyses.
Applications of Stable Isotope Labeled Peptides
Our stable isotope labeled peptides (SIL) serve critical roles in numerous research areas, offering unmatched precision and consistency:
- Reference Material for Mass Spectrometry Experiments (Proteomics): Isotope labeled peptides are crucial for the precise quantification and identification of proteins in complex biological samples, enhancing the accuracy of your proteomics research.
- NMR Studies: Utilize isotope labeled peptides in NMR to achieve detailed solution structure determination of peptides and proteins, providing insights into molecular interactions.
- Pharmacokinetic Analyses: Labeled peptides serve as reliable reference materials for drug metabolism and pharmacokinetic studies, ensuring accurate tracking of drug behavior in biological systems.
- Metabolite Identification: Facilitate the accurate identification of metabolites in metabolic studies, using isotope labeled peptides to trace biochemical pathways with confidence.
Our Expertise in Isotope Labeled Peptides
At JPT, we leverage over 20 years of expertise in peptide synthesis to deliver thousands of stable isotope labeled peptides annually. Our state-of-the-art laboratories in Berlin, Germany, operate under the latest ISO 9001:2015 regulations, ensuring the highest quality and reliability of our products.
Common Stable Isotope Labeled Amino Acids
We provide a comprehensive selection of stable isotope labeled amino acids, with custom options available upon request. The table below highlights some of our most frequently synthesized labeled amino acids:
| Amino Acid | One-Letter Code | Isotope | Mass Difference to non-labeled AA |
|---|---|---|---|
| Alanine | A | U- 13C3, U-15N | +4 Da |
| Arginine | R | U- 13C6, U-15N4 | +10 Da |
| Leucine | L | U- 13C6, U-15N | +7 Da |
| Lysine | K | U- 13C6, U-15N2 | +8 Da |
| Phenylalanine | F | U- 13C9, U-15N | +10 Da |
| Proline | P | U- 13C5, U-15N | +6 Da |
| Valine | V | U- 13C5, U-15N | +6 Da |
Why Choose JPT for Your Isotope Labeled Peptides?
- Tailored Solutions: From micro-scale synthesis (10-50 nmol) to intermediate peptide synthesis (1-100 mg), we cater to your specific needs with high throughput capacities.
- Customization Options: Select your desired peptide format (pool, library, microarray), purity level (from crude up to >98%), and optional modifications (phosphorylation, biotinylation, dye labeling, cyclization, conjugation, stable-isotope labeling, etc.).
- Advanced Labeling Methods: We use precise labeling methods to ensure the highest quality and consistency in our isotope labeled peptides.
Experience unparalleled expertise and quality with JPT Peptide Technologies, your trusted partner in peptide synthesis. Contact us today to discuss your specific requirements and discover how our stable isotope labeled peptides can enhance your research.
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