Peptide Chemistry

We have a substantial, long-standing expertise in peptide synthesis, providing tailored peptides with highest quality for even complex or unusual peptide sequences. Our highly skilled and committed scientific staff ensures that the most appropriate modifications, purities, methods, peptide synthesizers and techniques are selected for every custom peptide synthesis project.

Most of JPT's specialty peptides are provided in the highest purity (>95%), with a full range of peptide analyses including LC-MS (trap and/or quad), MALDI-MS or HPLC. A large variety of optional analyses is available e.g. AAA, NMR, CE, sterility testing, as well as peptide content determination.

The exceptional quality and reliability of our peptide synthesis service has been appreciated by customers worldwide for many years.

Specialties

This is a selection of common peptide modifications and labeling options. For a detailed description of the different options and a full list, please visit our Specialty Peptide Synthesis page.

Fluorescence and chromogenic labeled peptides (FITC, Carboxyfluorescein, Alexa, AMC, FRET peptides, etc.)
Peptide esters
Internally quenched peptides (FRET peptides: Abz/nitroTyr, EDANS/DABCYL, MCA/DNP labeling) guaranteed without fluorescent impurities
Immunogenic peptides (MAPs, palmitinylation, Pam3Cys labeling, etc.)
Phosphopeptides (phosphorylated tyrosine, threonine or serine) and peptidomimetics (amide bond isosteres, non-natural amino acids, etc.)
Post-translational modifications (PTMs) such as acetylation, methylation, phosphorylation, citrullination e.g. acetyl lysine and acetyl arginine peptides, methyl lysine and methyl arginine, citrullin, lysine succinyl, butyryl, propyl... etc.
Non-commercial building blocks for custom peptide synthesis
Biotinylated peptides (N-terminal and C-terminal biotinylation as well as biotin attached via side chains – via special optimized linker / spacer)
D amino acid peptides (D peptides)
Labeled custom peptides (stable isotope labeling (heavy peptides), chromophore, etc.)
Cyclic peptides (disulfide bridges, lactams, thioether-bridges, etc.)
Long peptides (>70 amino acids)
Site-directed conjugations of custom peptides with KLH, BSA, ovalbumine or other carriers

Please inquire about additional peptide modifications not listed here

References

Methods to Measure MDSC Immune Suppressive Activity In Vitro and In Vivo
Samantha Solito et al., Current Protocols in Protein Science (2018) - PMID: 30303619

A Versatile T cell-based Assay to Assess Therapeutic Antigen-specific PD-1-Targeted Approaches
Versteven et al., Oncotarget (2018) - PMID: 29963238

Decoy Peptides Derived from the Extracellular Domain of Toll-like receptor 2 (TLR2) show Anti-inflammatory Properties
Versteven et al., Bioorganic & Medicinal Chemistry (2018) - PMID: 29963238

Method For Inducing Oral Tolerance Via Administration of Beta-Lactoglobulin Derived Peptides in Combination With Probiotic
Knippels et al., US Patent App. 15/558,669 (2018) - PMID: n.a.

T‐cell tracking Using Cerenkov and Radioluminescence Imaging
Boschi et al., Journal of biophotonics (2018) - PMID: 29770603

Platelet Characteristics in Patients with Essential Thrombocytosis
Pedersen et al., Cytometry Part B: Clinical Cytometry (2018) - PMID: 29790256

Platelet Subpopulations Rremain Despite Strong Dual Agonist Stimulation and can be Characterised Using a Novel Six-Colour Flow Cytometry Protocol
Södergren et al., Scientific Reports (2018) - PMID: 29362366