PM-Pan-BKVselect-1

PepMix™ Pan-BKV Select

US$524.00

Description

Product Description

Virus-specific pool of 53 peptides (defined HLA class I & II-restricted T-cell epitopes) from selected proteins ofBK polyomavirus for T cell assays (e.g. ELISPOT).
Amount: 25 ug (approx. 15 nmol) / peptide (for stimulation of up to 2,5 x 108 cells)
Purity: >70% (HPLC-MS)
Delivery Format: Freeze-dried in glass vial
Application(s): Antigen specific T-cell stimulation, Immune monitoring, T-cell assays, T-cell expansion
Indication(s)/Topic(s): Merkel cell carcinoma
Delivery Time: 2-5 days

PepMix™ Select
PepMixes™ Select are able to elicit virus-specific strong immune responses by using only immunodominant epitopes covering various antigens of the same pathogen in one peptide pool. They can be used individually, or in combination, with our market-leading antigen-spanning PepMixes™ to boost an immune response. Applications include generation of virus-specific T cells, pulsing experiments or extended immune monitoring.

Benefits of PepMix™
- Produced under stringent ISO 9001 regulations
- Each peptide quality controlled and guaranteed for identity and purity
- CoA and HPLC-MS data available for each individual peptide batch
- High batch-to-batch consistency
- No false positive T cell responses by contaminating deletion peptides
- No toxic inhibition of T cell responses due to stringent purification of each peptide
- Minimization of endotoxin contamination due to low bioburden process
- ADCF policy in place

References

References for PepMix™ Pan-BKV Select

References
Read References with
PepMix™ Peptide Pools for Infectious Diseases
COVID-19 related PepMixes™
PepMix™ Control Pools

Application Notes
Peptide Tools to Support the Fight against COVID-19
Alem et al (2020) Full text
Developing Multi-HIV Antigen Specific T-Cells as a Component of a Cure Strategy
Lam et al. (2015) Full text
Peptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell Transplantation
Gary et al. (2015) Full text

Testimonials
"To establish a novel role for myeloid derived suppressor cells (Pallett et al, Nat. Med. 2015) in chronic viral infection, we utilised the PepMix CEF Pool (extended) as well as a custom synthesized PepMix spanning the core region of HBV genotype D . Whereas, the CEF peptide pool consists of 32 peptides, each corresponding to a defined HLA class I-restricted T-cell epitope from Cytomegalo, Epstein-Barr, and Influenza virus, the latter custom PepMix included 15meric peptides overlapping by 10 amino acids. Specifically this composition enabled us to monitor both the antiviral CD8+ and CD4+ T cell responses in chronic HBV infection and the non-antigen specific T cells that are known to mediate immunopathology in the liver. Our entire experience with JPT, from ordering/delivery to use in the lab was excellent. Not only were the reagents able to perform reliably and consistently in vitro from batch to batch, the customer and technical support provided was continually available and efficient when needed. JPT will remain our go-to company for purchasing peptides."
Dr. Laura J Pallett, Infection and Immunity, University College London, UK

Documentation

Documentation for PepMix™ Pan-BKV Select

Properties

Properties of PepMix™ Pan-BKV Select

Properties Values
Application: Antigen specific T-cell stimulation, Immune monitoring, T-cell assays, T-cell expansion
Category: PepMix Peptide Pools
Indication / Topic: Merkel cell carcinoma
Layout: Freeze-dried in glass vial
Organism: BK polyomavirus
Protein Name: Selected proteins
amount: 15 nmol (approx. 25ug) / peptide for stimulation of 2,5 x 108 cells, 25 ug (approx. 15 nmol) / peptide (for stimulation of up to 2,5 x 108 cells), 25 ug (approx. 15 nmol) / peptide for stimulation of 2,5 x 108 cells
purity: >70% (HPLC-MS)

Further Information to PepMix™ Pan-BKV Select

Information Values
Sequence: see additional product documentation
Specifications: Defined HLA class I& II-restricted T-cell epitopes
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TÜV Rheinland certified
Health - made in Germany
Quality Assurance

All production is performed according to ISO 9001:2015 standards.