Bioinformatics, Cheminformatics, Molecular Modeling

JPT has a long standing and focused expertise to assist biomedical screening and peptide lead optimization programs with its comprehensive bioinformatic and cheminformatic capabilities. Statistical evaluation as well as visualization and presentation of complex data are performed using state of the art tools.

We offer this unique know-how and expertise as part of our services or in R&D collaborations.

Service Specifications

Detailed discussion of your project and definition of a suitable strategy based on scientific feasibility and experience
Receive project proposal on how our bioinformatics and cheminformatic expertise can support your project
Obtain detailed and comprehensive service reports

Applications

Design of peptide content for high-density peptide microarrays and complex peptide libraries
Design of peptide libraries based on biological pathways, literature data or complex database search strategies
Generation of homology models and use of available structural information for peptide selection
Optimization of hit and lead structures (affinity, physicochemical properties, ADME)
Prediction and modeling of data
Scaffold design for native-like presentation of peptides
Interpretation, management and integration of data
Visualization and presentation of complex data sets

Benefits

Long-term track record in the discovery and development of peptides in drug discovery and diagnostic development
State-of-the-art prediction, data interpretation and data mining algorithms and software paired with chemical and biological know-how
Expertise available as a fee-for-service or in collaborative partnerships

References

Probing the Epitope Signatures of IgG Antibodies in Human Serum from Patients with Autoimmune Disease
Lorenz et al., Methods Mol. Biol. (2009) - PMID: 19377950
Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip AnalysisRepresenting 61 Proteins from M. tuberculosis
Gaseitsiwe et al., PLoS One (2008)- PMID: 19065269
Design and Synthesis of a New Class of Selective Integrin α5β1 Antagonists
Stragies et al., J. of Medicinal Chemistry (2007) - PMID: 17616113
Translating Peptides into Small Molecules
Hummel et al., Mol. BioSyst. (2006) - PMID: 17216031