Proteomics

JPT provides a multitude of innovative research tools to the proteomics community. Besides high-throughput chemical and analytical approaches to accelerate discovery of novel biomarkers from biological samples, JPT developed a new mass spectrometry-based peptide standard technique for absolute quantification of target proteins in clinical and targeted proteomics. Furthermore, JPT has a decade-long track record providing services and project expertise in the area of functional proteomics ranging from elucidation of protein-protein interactions and enzymatic activities to epigenetic regulation.

Applications

Applications

  • Target discovery and validation: we evaluate the effect of your target protein in biological networks
  • Biomarker discovery: we quantify hundreds of proteins, e.g. tumor associated antigens from patient blood samples in one experiment, and correlate the quantities and post-translational modification status with clinical data
  • Clinical monitoring: monitoring the effect of therapeutic intervention and disease status is vital to understand and describe the effects of applied drugs on target proteins; especially the parallel quantification of large numbers of relevant proteins will facilitate personalized medicine approaches, patient stratification and companion diagnostic development
  • Proteome wide quantification of proteins and protein modification states
  • Proteome wide characterization of enzymatic activities or enzyme families
Benefits

Benefits

  • Proprietary high throughput peptide technologies for highly multiplexed identification of proteins
  • Unique approach for absolute and multiplexed quantification of proteins
  • Coverage of post-translational modifications
  • Rapid access to hundreds of thousands of peptides overing the entire human proteome
References

References

  • Prosit: Proteome-wide Prediction of Peptide Tandem Mass Spectra by Deep Learning
    Gessulat et al, Nature Methods (2019)
  • Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD)
    Wilson et al, Proteomes (2019)
  • A Deep Proteome and Transcriptome Abundance Atlas of 29 Healthy Human Tissues
    Wang et al, Molecular Systems Biology (2019)
  • Mining the Human Tissue Proteome for Protein Citrullination
    Lee et al, Molecular & Cellular Proteomics (2018)
  • ProteomeTools: Systematic Characterization of 21 Post-Translational Protein Modifications by LC-MS/MS Using Synthetic Peptides
    Zolg et al, Molecular & Cellular Proteomics (2018)
  • Analysis of Histone Modifications by Mass Spectrometry
    Völker‐Albert et al, Current Protocols in Protein Science (2018)


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