Drug Discovery & Optimization

JPT Peptide Technologies applies its proprietary peptide technologies, bioinformatic and medicinal chemistry know-how and decade-long track record managing R&D projects contract research and R&D collaborations in the following areas:

Peptide Discovery Hit to Lead / Qualification Peptide Optimization

Our experience in Drug Discovery and Optimization can be applied in peptide based drug and vaccine projects, in the discovery of peptidic additives for the cosmetic and nutritional industry, in the development of affinity ligands for the purification of biomolecules, as well as in content determination for novel immune diagnostics.

Applications

Discovery of peptidic agonistic or antagonistic ligands for proteins, protein complexes or antibodies
Optimization of peptides in terms of binding affinity, agonistic or antagonistic efficacy and physicochemical and PK properties
Identification and optimization of affinity ligands for the purification of therapeutic proteins or antibodies
Identification and optimization for the development of alternative binding assays for complicated target proteins (e.g. membrane proteins)
Development of peptides as active ingredients or excipients in drug formulations (e.g. to increase stability) or nutritional and cosmetic products, respectively

References

Detection of Neurogenerative Diseases
Moussaoui et al, Patent WO 2017/153922 (2017)

Peptide Mimotopes of the CD3 T-Cell Co-Receptor Epsilon Chain and uses thereof
Schnatbaum et al, Patent WO 2017/008844 (2015)

Peptide Mimotopes of Claudin 18.2 and uses thereof
Schnatbaum et al, Patent WO 2015/113576 (2014)

Peptide Microarrays Enable Rapid Mimotope Optimization for Pharmacokinetic Analysis of the Novel Therapeutic Antibody IMAB362
Schnatbaum et al., Biotechnol J. (2014) - PMID: 24497417

More references