Z-Arg-Arg-AMC (Z-RR-AMC) is a fluorogenic peptide substrate commonly used to monitor cathepsin B and cysteine protease activity. Cleavage of the Arg-Arg-AMC substrate releases 7-amino-4-methylcoumarin (AMC), enabling sensitive fluorescence-based measurement of proteolytic activity.
Product Specifications
- Product Code: SP-CAT-092
- Sequence: Cbz-RR-AMC
- CAS Number: 88937-61-5
- Molecular Formula: C30H39N9O6
- Molecular Weight: 621.70 g/mol
- Purity: >95% (HPLC-MS)
- Amount: 5 mg
- Format: Freeze-dried in plastic vial
- Storage: Store at -20°C
- Standard Delivery Time: 2-5 days
Applications
- Cathepsin B activity assays
- Cysteine protease research
- Fluorescence-based enzyme assays
- Enzyme kinetics
- Protease inhibitor studies
Fluorogenic Protease Substrates for Cathepsin Research
Z-Arg-Arg-AMC is included in JPT's Protease Substrates portfolio for studying protease activity through defined peptide cleavage reactions. The range supports cathepsin research, enzyme kinetics, substrate profiling and evaluation of protease inhibitors in biochemical assays.
Benefits of Z-Arg-Arg-AMC and JPT Protease Substrates
The Arg-Arg-AMC format provides a sensitive fluorogenic readout for cathepsin B-focused protease assays and kinetic measurements. JPT Protease Substrates offer characterized synthetic peptide reagents that can be integrated into activity, specificity and inhibition workflows.
Looking for another cathepsin substrate or reporter format?JPT Custom Peptide Synthesis enables custom protease substrates with alternative sequences, fluorophores, modifications, quantities and purity specifications for individual research projects.
