 - CAS 203716-10-3.jpg "Transportan 10 (TP10) - CAS 203716-10-3")
SP-CAT-024
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Transportan 10 or TP10 is a well-characterized cell penetrating or cell-permeable peptide that can be conjugated to nucleic acids and other macromolecules. It can penetrate many cell types in a rapid and efficient way by interating with the lipid bilayer. Transportan comprises part of the amino terminus of the neuropeptide galanin and the carboxyl terminus of mastoparan, connected via a lysine. Therefore, TP10 is able to inhibit galanin binding to the GALR-1 receptor and to modulate the activity of G proteins through inhibition of GTPase. Described by Pooga et al. 1998; Soomets et al. 2000.
Cell Penetrating Peptides (CPPs) are capable of crossing cellular membranes, facilitating the delivery of various therapeutic and experimental cargoes, such as bioactive molecules, into cells. Their ability to transport molecules that otherwise cannot penetrate cell membranes, such as proteins, peptides, and even large nucleic acids like plasmid DNA or RNA, makes them indispensable for both fundamental research and clinical applications. JPT Peptide Technologies has substantial, long-standing expertise in providing peptides in all formats, scales and modifications to the global scientific community. All our catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.
Benefits of JPT’s PeptidesReferences:
Read References with Specialty Peptides
Testimonial:
"Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle."
Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands
Testimonial:
Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle.
Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands
| Properties | Values |
|---|---|
| Amount: | 1 mg |
| Application: | Drug delivery |
| Category: | Cell-Penetrating Peptides |
| Condition / Topic: | Cancer, Gene therapy |
| Layout: | Freeze-dried in plastic vial |
| Organism: | Human |
| Protein Name: | CPP |
| Purity: | Trial Grade: each peptide purified to > 90% (HPLC/MS) |
| Quantification: | Yes |
| Information | Values |
|---|---|
| Sequence: | H-AGYLLGKINLKALAALAKKIL-NH2 |
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