ULTRA pools represent sequence diversity with the least possible number of peptides for
- Cellular immune monitoring
- Stimulation of T-cells
- Development of vaccines or immunotherapy
Our proprietary ULTRA algorithm was designed to reflect the full spectrum of sequence variation of a virus or type of cancer within one peptide library. This saves precious time and resources.
Our algorithm creates all possible peptide variations and scores these according to their frequency of occurrence across all sequences. We can then define the optimal overlap required to provide homogeneous overall coverage.
Sequence Diversity in Viruses
- Hallmark in many pathogenic viruses including HIV, HBV and SARS-CoV-2
- Mostly found in viral envelope proteins, due to their important role in eliciting host immune recognition
- Important for the design of antigen-based products, intended for immune monitoring and vaccination
Sequence Diversity in Tumors
- 10 000 to 12 000 sites with coding mutations have been identified in humans, translating into a sequence alteration in one of every two genes
- Somatic mutations cause sequence heterogeneity within individuals which are of special significance in the pathological mechanisms of cancer
- 767 germline and 29881 somatic mutations have been identified for TP53, one of the most important tumor driver genes