Matrix Pools have a specialized layout that enables fast and minimal material consuming identification of epitopes within an antigen. From a given antigen overlapping peptides are generated and pooled into many subpools.
Each peptide is present in exactly two subpools according to a layout that we design for each antigen.
In the example shown below 64 peptides are pooled into 16 Matrix Pools. Pools V and XIII elicit a positive T-cell response. Only peptide 37 is present in both pools and therefore is the peptide containing the epitope.
Matrix Pools are also the main component of Epitope Mapping Peptide Sets (EMPS).
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