ULTRA libraries are used to represent sequence diversity with the least possible number of peptides for
- Immune monitoring of T- and B-cell response
- T-cell stimulation in immunotherapy
- Biomarker discovery
- Development of vaccines
We generate ULTRA libraries with our proprietary algorithm to reflect the full spectrum of sequence variation within a virus or type of cancer with one comprehensive peptide library. This saves precious time and resources.
Our algorithm creates all possible peptide variations and scores these according to their frequency of occurrence across all sequences. We can then define the optimal overlap required to provide homogeneous overall coverage.
Sequence Diversity in Viruses
- Hallmark in many pathogenic viruses including HIV, HBV, Influenza and SARS-CoV-2
- Most sequence diversity found in viral envelope proteins, due to their important role in eliciting host immune recognition
- Sequence diversity has to be taken into account in the design of antigen-based products, intended for immune monitoring and vaccination
Sequence Diversity in Tumors
- 10 000 to 12 000 sites with coding mutations have been identified per individual, translating into a sequence alteration in one of every two genes
- Somatic mutations cause sequence heterogeneity within individuals which are of special significance in the pathological mechanisms of cancer
- 767 germline and 29881 somatic mutations have been identified for TP53, one of the most important tumor driver genes