Positional Scanning Library

A Positional Scanning Library is used to

  • Increase activity of enzyme substrates
  • Enhance antibody epitopes
  • Improve T-cell epitopes
  • Optimize peptide binding sites

Positional Scanning Libraries are generated by systematically replacing one or more selected residues within a peptide sequence by all other natural (or non-natural) amino acids. Amino acids that increase activity or binding can be identified by using a positional scanning library and a sequence with improved properties is designed.


In combinatorial positional scanning libraries 2 or more residues at different positions are varied in each peptide taking effects of multiple positions on the biological activity of a peptide sequence into account.


Use our free and easy-to-use PepSequencer for generation of positional scanning libraries!


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peptide library design positional scanning analysis
peptide library design positional scanning analysis
peptide library design positional scanning analysis