Peptide Stability Testing

Peptides have an inherent and sequence specific stability profile which depends on the properties of the individual peptides and storage conditions. Degradation of peptides during storage can be attributed to a variety of chemical reactions such as oxidation, hydrolysis, structural rearrangements and more. Despite this knowledge, stability of a given peptide is hard to predict. Stability testing is therefore advisable for certain applications and performed to determine the short and long term stability of peptides.

  • Peptide aliquots are stored under defined conditions (e.g. -20°C, -80°C, room temperature)
  • They are analyzed by HPLC-MS at certain time points (e.g. 3 months, 6 months, 12 months)
  • Acquired data demonstrate HPLC purity of peptides under the tested conditions in the recorded time frame
  • This information is useful to determine expiry dates and necessary storage conditions for peptides
  • In order to predict long term stability of peptides in a short time frame, a stress stability test at elevated temperatures (e.g. 40°C) can be performed

Material requisition: approx. 1 mg/sample

Time needed: depends on time points

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