Matrix Pools have a specialized layout that enables fast and minimal material consuming identification of epitopes within an antigen. From a given antigen overlapping peptides are generated and pooled into many subpools.
Each peptide is present in exactly two subpools according to a layout that we design for each antigen.
In the example shown below 64 peptides are pooled into 16 Matrix Pools. Pools V and XIII elicit a positive T-cell response. Only peptide 37 is present in both pools and therefore is the peptide containing the epitope.
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