Peptide cyclizationlibraries consisting of cyclic peptides (cyclized peptides) are used for
- Development of peptides with enhanced bio stability
- Mimicking secondary protein structures (e.g. protein loops)
- Optimizing peptides (e.g. peptide ligands with increased binding potency/selectivity and enhanced protease stability)
For a cyclization library cyclic peptides can be synthesized by different methods, e.g. head-to-tail cyclization, side-chain-to-side-chain, head-to-side-chain, and side-chain-to-tail cyclization.
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