SPT-TAA

SpikeTides™ Set TAA - light

US$279.00

Description

Product Description

Collection of 252 representative proteotypic peptides for tumor associated antigens derived from 61 annotated human proteins for direct usage in mass-spectrometry based proteomics (MRM).

Amount: approx. 50-150 pmol per peptide
Purity: crude
Delivery Format: 96 well microtiter plate
Application(s): Mass spectrometry, Proteomics
Indication(s)/Topic(s): Breast cancer, Burkitt's lymphoma, Cancer, Gastric cancer, Malignant genital cancers, Melanoma, Prostate cancer
Delivery Time: 2-5 days

JPT's SpikeTides™ Sets TAA
JPT produced a set of proteotypic peptides for the detection of the most relevant tumor associated antigens (TAA) by mass-spectrometry based proteomics. 75 TAAs were selected and prioritized in a NCI pilot project to rank the most relevant cancer antigens to date (Cheever et al., 2009). For 61 of these TAAs JPT'synthesized proteotypic peptides with well documented MRM transition data available (www.srmatlas.org, ISB) resulting in a set of 252 proteotypic peptides for important tumor associated antigens. This set is available with light or isotopically labeled (C-terminal Arg U-13C6;U-15N4 or Lys U-13C6;U-15N2) peptides and is delivered in three 96 well plates.

Benefits of JPT's SpikeTides™ Sets TAA
- Relative quantification of multiple TAA’s from a single sample
- First economic heavy peptide set available
- Multiplexed analysis of disease status and therapeutic success

References

References for SpikeTides™ Set TAA - light

References:
Read References with Reference Peptides for Targeted Proteomics - SpikeTides™ & SpikeMix™

Application Notes
Development of a Multiplexed Targeted SRM Assay for NCI’s Top Tumor Associated Antigens
Soderblom et al., Application Note (2015) Full text
Absolute Quantification of Metabolic Enzymes via Targeted Proteomics using a new Kit of SpikeTides™ Peptides
Bindel et al., Application Note (2015) Full text
Development and Characterization of SpikeMix™ ABRF (cross-Species Standard) Consisting of 1,000 Stable Isotope Labeled Peptides
Colangelo, Application Note (2014) Full text

Testimonials
"As Director of the Protein Profiling at Yale Keck Biotechnology Resource Facility, I coordinated a collaboration between the Association of Biomolecular Resource Facilities (ABRF) standard proteomic research group (sPRG) and JPT Peptide Technologies to develop the ABRF cross-species SpikeMix™ peptide pool. The joint development turned out to be an extraordinary effective endeavor and the resulting product was qualified in more than 52 proteomics labs around the globe. I was impressed by JPT's scientific and technological capabilities as well as their enthusiasm to drive the project forward."
Christopher M. Colangelo, Director of Protein Profiling at Keck Biotechnology Resource Facility, Yale University, USA

"Our research at Stanford University seeks to discover unconventional translation products, and proteins made by unsequenced organisms; to characterize a wide array of protein post-translational modifications; and to perform peptide antigen binding assays. On all of these fronts, we are in need of high quality peptide standards for assay development and protein quantification. The successful collaboration with the team at JPT Peptide Technologies and their wide range of products has been a critical factor for advancing my group's research."
Joshua E. Elias, Ph.D., Assistant Professor, Chemical & Systems Biology, Stanford University School of Medicine, Clark Center, Stanford, CA

Documentation
Properties

Properties of SpikeTides™ Set TAA - light

Properties Values
Application: Mass spectrometry, Proteomics
Category: SpikeTides™ Reference Peptides
Indication / Topic: Breast cancer, Burkitt's lymphoma, Cancer, Gastric cancer, Malignant genital cancers, Melanoma, Prostate cancer
Layout: 96 well microtiter plate
Organism: Homo sapiens (Human)
Protein Name: Selected proteins
amount: approx. 50-150 pmol per peptide
purity: crude

Further Information to SpikeTides™ Set TAA - light

Information Values
Sequence: See Layout and Sequences under Product Documentation
Specifications: 252 representative proteotypic peptides for 61 human tumor associated proteins in 96 well plates
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Quality Assurance

All production is performed according to ISO 9001:2015 standards.