Immune Monitoring

Cancer neo-antigens are considered important targets for personalized cancer immunotherapy. However, development and application of patient-specific cancer therapies pose a challenge to fast, flexible and cost effective ways to monitor the immune response to these treatments. Overlapping, neo-epitope spanning peptide libraries, pools and arrays represent efficient immune monitoring tools for both humoral and cellular immune responses. Because each patient requires a different, individually synthesized set of peptides, standard commercial approaches to peptide synthesis deliver neither the speed nor the capacity required for large trials. We bridge this gap by offering unique peptide formats for the specific needs of immune monitoring when developing neo-epitope based therapies. Our high-throughput peptide synthesis approach paired with automated liquid handling as well as a proprietary peptide microarray technology provide access to a large selection of peptide formats. This enables cellular and humoral immune monitoring for individualized neo-epitope based immunotherapy trials.

PepTrack™ Peptide Libraries for T-Cell Assays
Our customized peptide libraries with flexible format and specifications are optimized for cellular immune monitoring assays such as ELISpot, flow cytometry or cytokine staining assays.
SpotMix™ Antigen Discovery Pools
SpotMixes™ represent overlapping & pooled peptides generated with our proprietary ultra-high throughput SPOT technology and are a quick and economical solution for immune monitoring in neo-epitope therapy development and discovery projects.
PepStar™ Peptide Microarrays
JPT offers PepStar™ peptide microarrays for profiling of cancer specific samples or antibodies, detection of epitopes or neo-epitopes, vaccine target identification, and monitoring epitope spreading. Peptide microarrays are reliable and efficient tools for screening assays such as the characterization of potential therapeutic antibodies, the identification of novel biomarkers, and the elucidation of protein/protein interactions.
Peptide microarrays can display overlapping peptide scans through antigens, or any other peptide sequences. You define the content and format and we provide economical and fast production of customized PepStar™ peptide micorarrays in our regulated clean-room environment. Or you can choose one of our off-the-shelf peptide microarrays display overlapping peptide scans through numerous antigenic proteins.

Peptide ELISA
We offer customized peptide-coated ELISA (enzyme-linked immunosorbent assay) plates . ELISA is a well-established analytical and highly sensitive immunological assay for proteins but requires detailed experimental know-how for using peptides. Peptide ELISA is used for mapping of epitopes, neo-epitopes and definition of protein interaction sites or as a validation assay to confirm results obtained with JPT’s peptide microarrays.

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PepSpots™ Peptide Arrays on Membrane
PepSpots™ are membrane-bound peptide arrays used for efficient and inexpensive antibody epitope mapping and protein-protein interaction studies. Peptides are synthesized by our proprietary SPOT technology directly on hydrophilic cellulose membranes, which minimize non-specific binding. Easy detection using standard ELISA protocols.

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use of neo epitope immune monitoring
use of neo epitope immune monitoring
use of neo epitope immune monitoring