Humoral Immune Monitoring

Our proprietary peptide-based humoral immune monitoring technologies allow high resolution profiling of antibody related immune responses. Purified antibodies, patient sera and even whole blood can be used with our assay platforms targeting specific antigens, entire antigen families or selected epitopes and neo-epitopes. This allows effective B-cell epitope resolved elucidation of antibody responses in clinical studies as well as recognition of certain epitope patterns and epitope spreading. Additionally, we can address natural sequence diversity, mutations and post-translational modifications that occur in cancer cells and different types of viruses.

PepStar™ Peptide Microarrays

JPT offers PepStar™ peptide microarrays for profiling of cancer specific samples or antibodies, detection of epitopes or neo-epitopes, vaccine target identification, and monitoring epitope spreading. Peptide microarrays are reliable and efficient tools for screening assays such as the characterization of potential therapeutic antibodies, the identification of novel biomarkers, and the elucidation of protein-protein interactions.

Peptide microarrays can display overlapping peptide scans through antigens, or any other peptide sequences. You define content and layout and we provide economic and fast production of customized PepStar™ peptide micorarrays in our regulated clean-room environment. Or you can choose one of our off-the-shelf peptide microarrays display overlapping peptide scans through antigenic proteins.

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Peptide ELISA

We offer customized peptide-coated ELISA plates (enzyme-linked immunosorbent assay). ELISA is a well-established analytical and highly sensitive immunological assay for proteins but requires detailed experimental know-how for using peptides. Peptide ELISA is used for mapping of epitopes and definition of protein interaction sites or as a validation assay to confirm results obtained with JPT’s peptide microarrays.

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PepSpots Peptide Arrays on Membrane

PepSpots are membrane-bound peptide arrays used for efficient and inexpensive antibody epitope mapping and protein-protein interaction studies. Peptides are synthesized by our proprietary SPOT technology directly on hydrophilic cellulose membranes, which minimize non-specific binding. Easy detection using standard ELISA protocols.

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