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SpotMix™ Antigen Discovery Pools

SpotMix™ Antigen Discovery Pools consist of overlapping & pooled peptides synthesized by our proprietary ultra-high throughput SPOT technology.  SPOT peptides are synthesized in small amounts fully automated and are unpurified. Therefore, we are able to provide SpotMix™ and SpotMix™ PLUS Pools very quickly and at low cost. SpotMix™ Pools are optimal for broad antigen target discovery, deep T-cell epitope discovery and biological screening. SpotMix™ PLUS Pools have also been used for neo-epitope based immune monitoring. 

Have a look at all our Epitope Discovery & Target Discovery Tools for Development of Cell- and Immunotherapy

Differences between SpotMix™ & PepMix™ Peptide Pools

spotmix™ spotmix™plus customized pepmix™
Amount/Peptide
Varying (approx. 5 to 20 µg / peptide depending on synthesis yield) 10 µg / peptide (each peptide quantified) From 1 mg / peptide (each peptide quantified)
Peptide Purity
Unpurified Unpurified Unpurified to GxP grade
Peptide QC
5% peptides analyzed by LC-MS 100% peptides analyzed by LC-MS 100% peptides analyzed by LC-MS
Pool QC
none none Full QC for each peptide pool warranting presence of each peptide
Applications
Antigen discovery Neo-epitope based immune monitoring, Antigen discovery Clinical immune monitoring, preclinical & clinical research, immunotherapy
Delivery Time
From 2 weeks From 3 weeks From 4 weeks
Price/Peptide
11€/$11 17€/$17 From 34,50€/$38.50

    

Applications for SpotMix™ Antigen Discovery Pools

  • Antigen target discovery
  • Deep T-cell epitope discovery
  • Biological screening
  • Neo-epitope based immune monitoring

Application Notes:
A Fast & Low Cost Process for Neo-Epitope Based Immune Monitoring
by Evelyna Derhovanessian, BioNTech AG, Mainz, Germany
Strategy for Identification of CD8 T‐cell Epitopes in a Viral Protein
by Regina Holtappels, Institute for Virology and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg‐University, Mainz, Germany

Benefits of SpotMix™ Antigen Discovery Pools

  • Quick production
  • Parallel production of thousands of peptides resulting in hundreds of peptide pools
  • Most inexpensive custom peptide pools in the market

References for SpotMix™ Antigen Discovery Pools

"Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library"
Lewinsohn et al., PLOS one (2013)
"Proteome-Wide Screening Reveals Immunodominance in the CD8 T Cell Response against Classical Swine Fever Virus with Antigen-Specificity Dependent on MHC Class I Haplotype Expression"
Franzoni et al., PLOS one (2013)
"Screening of Predicted Secreted Antigens from Mycobacterium bovis Reveals the Immunodominance of the ESAT-6 Protein Family"
Jones et al., Infect Immun (2010)

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