RepliTope™ Peptide Microarrays
RepliTope™ peptide microarrays are off-the shelf peptide microarrays, displaying overlapping peptide scans through antigenic proteins. RepliTope™ peptide microarrays are reliable and efficient tools for screening assays such as the characterization of potential therapeutic antibodies, the identification of novel biomarkers, and the elucidation of protein/protein and enzyme/substrate interactions. Additionally, we offer our comprehensive Peptide Microarray Assay and Incubation Service for outsourcing of experiments.
RepliTope™ Peptide Microarrays for Infectious Diseases
RepliTope™ Antigen Collection Catalog Peptide Microarrays
RepliTope™ Peptide Microarrays for Tumor Associated Antigens
Incubation Kit & Accessories
Applications for RepliTope™ Peptide Microarrays
- Screening of seromarkers for infectious and autoimmune diseases, allergies and cancer
- Development of phosphorylation dependent antibodies
- Epitope mapping using only minimal amounts of antibody
- Individual or parallel antibody profiling
- Profiling of neutralizing antibody action
- Immune Monitoring of humoral immune responses during clinical trials
"The Challenge of Antigen Sequence Diversity: Solutions with ULTRA‐Peptide Libraries"
by Pawlowski et al.
"Multiple Sclerosis and Epstein‐Barr Virus Infection. An Epitope Mapping Study"
by Reimer et al.
"Antibody Signatures Defined by High-content Peptide Microarray Analysis"
by Schutkowski et al.
"The Other Microarrays: Detailed Mapping of Humoral Immune Response Using JPT Peptide Technologies' Peptide Microarrays and Tecan Array Technology"
by Pawlowski et al.
Benefits of RepliTope™ Peptide Microarrays
Testimonials for RepliTope™ Catalog Peptide Microarrays
"One focus of our group is to decipher the nature of immune responses by identification of biomarkers and indicators of immune protection. With the support of JPT's high content peptide microarray platform, we created a peptide chip which contains 22.000 individual peptides. This enabled the visualization of the B-cell "signature" in individuals with TB-infection vs. non- infected individuals. In our hands, JPT's peptide microarrays turned out to be very robust tools to identify novel peptide based biomarkers in the context of novel diagnostics and vaccine target identification."
Prof. Markus Maeurer, Karolinska Institute Sweden, Solna, Sweden
Selected References for RepliTope™ Peptide Microarrays
Superior Efficacy of an HIV Vaccine Combined with ARV Prevention in SHIV Challenged Non-human Primates
Le Grand et al., Journal of Virology (2016) - PMID: 27009957
Protective Efficacy of Adenovirus-protein Vaccines Against SIV Challenges in Rhesus Monkeys
Barouch et al., Science (2015) - PMID: 26138104
Structure of GPN-loop GTPase Npa3 and Implications for RNA Polymerase II Assembly
Niesser t al., Mol Cell Biol. (2015) - PMID: 26711263
Identification and Characterization of Common B Cell Epitope in Bovine Leukemia Virus via High-throughput Peptide Screening System in Infected Cattle
Bai et al., Retrovirology (2015) - 26715158
Peptide Microarrays for Coverage of Sequence Diversity in Monitoring the B cell Immune Response (TECH2P.911)
Castro, et al., The Journal of Immunology (2015) - PMID: n.a.
H1N1 Viral Proteome Peptide Microarray Predicts Individuals at Risk for H1N1 Infection and Segregates Infection Versus Pandemrix® -Vaccination
Aditya et al., Immunology (2015) - PMID: 25639813
HIV-1 Envelope Proteins and V1/V2 Domain Scaffolds with Mannose-5 to Improve the Magnitude and Quality of Protective Antibody Responses to HIV-1
Morales et al., The journal of Biological Chemistry (2014) - PMID: 24872420
Whole CMV Proteome Pattern Recognition Analysis after HSCT Identifies Unique Epitope Targets Associated with the CMV Status
Pérez-Bercoff et al., PloSONE (2014) - PMID: 24740411
Generation and Characterization of Mouse Monoclonal Antibodies Against NS4B Protein of Dengue Virus
Xie et al., Virology (2014) - PMID: 24503088