Phosphopeptides (Phosphorylated Peptides)
The site-specific synthesis of phosphorylated peptides(phospho peptides) is crucial for investigating phosphorylation events. Phosphopeptides are produced by the specific incorporation of protected phospho-amino acids or the "post-assembly" peptide phosphorylation at serine, threonine or tyrosine residues. Using the best suited approach for each phospho peptide, JPT has successfully synthesized thousands of phosphorylated peptides in recent years.
Protein Phosphorylation
- Plays a major role in many physiological processes
- Is one of the most studied post-translational modifications
- It regulates cell cycle, apoptosis and signal transduction pathways
- It occurs mainly on the hydroxyl side chain of serine and threonine residues
- It occurs to a lesser extent on the phenolic side chain of tyrosine residues
Phosphopeptides
- Function as control peptides for kinase profiling
- Are used as phosphatase substrates
- Serve as lead structures for phosphatase inhibitor discovery
In addition to traditional phosphopeptide synthesis, JPT provides a number of innovative solutions for kinase and phosphatase inhibitor design, screening and optimization, which are among the most efficient in industry.
Phosphopeptides Products & Services
- Kinase substrate microarrays: Screen >700 kinase substrates with extremely low sample requirement.
- Kinase substrate sets: Efficient kinase substrate screening.
- Peptide optimization service: Discuss your kinase substrate optimization needs with us and collaboratively discover new substrates.
Phosphate Analogs used in Phosphopeptides
Phosphorylated peptides have limited stability in biological fluids due to the presence of phosphatases. To circumvent this problem, hydrolytically stable phosphate analogs can be incorporated into peptides. Here we show some examples of such phosphate mimetics.
Please also have a look at our PTM Reference & Kits for direct usage as reference material in mass-spectrometry based proteomics to support PTM proteomics.
Phospho Tyr Analogs
Phospho Serine & Threonine Analogs
Depending on the peptide sequence and specification, JPT is able to incorporate the above mentioned analogs into many peptides.
Please contact us to discuss all options.
Request a price for
Custom Peptide Synthesis
News Highlights
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Boost Peptide Reliability with Peptide Analysis Services
JPT not only is the expert for peptide synthesis, but also conducts a wide variety of peptide analysis services.
(July 2019) -
Improve your Assays with PTM Reference Peptide Standards
(June 2018) -
JPT launches The Human Proteome Peptide Catalog
(April 2018)
--> Read more news
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