Histone Code Analysis Service
Histones are subject to post-translational modifications (epigenetic marks) that influence chromatin structures. The histone code hypothesis suggests that combinations of these modifications play a role in the regulation of gene expression.
Based on our high content histone code peptide microarray we offer a unique histone code analysis service. The microarray presents 3800 unmodified and modified histone peptides that carry most possible modifications, including acetylation, methylation, butyrylation, propylation, succinylation, malonylation, citrullination and phosphorylation as well as various combinations.
Our microarray features:
- Histone tails with various composite histone marks for identification of antibody epitopes including possibly occluded epitopes
- Core sequences with modifications representing the growing number of identified modifications within the histone cores
- Variant sequences enabling the analysis of preferred non-canonical over canonical histones
Applications for Histone Analysis Service
- Mapping and validation of protein-histone interactions including PTM dependencies
- Testing of histone antibodies including PTM dependencies
- Enzymatic activity profiling including PTMs
- Histone reader profiling
Application Note:
Use of High-Density Histone Peptide Arrays for Parsing the Specificity of a Histone-Modifying Enzyme Complex
by Shechter et al.
Benefits of Histone Analysis Service
- Coverage of all known natural variants (sequence variants and PTMs)
- All-in-one assays service including incubation and analysis
- Tailored peptide microarrays upon request
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All production is performed according to ISO 9001:2015 standards
