Cysteine modifications in cysteine-containing proteins are synthesized in vivo in several ways (see below). Oxidation reactions, lead to disulfides or cysteine sulfonic acid. Pam3Cys is a cysteine modification found in bacterial proteins and is used for promoting immune stimulation.
For peptides used in proteomics experiments, cysteines are usually carbamidoylated. This can be done post synthesis using iodoacetamide, or by employing a suitable CAMC building block during synthesis.
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