Beta Amyloid A4 Peptides for Alzheimer's Disease Research
The A beta peptide (synonyms are Beta Amyloid peptide or Abeta peptide) is the main component of amyloid peptide plaques in the brain of patients with Alzheimer's disease. JPT provides a broad selection of chemically synthesized amyloid beta peptides for Alzheimer's disease research. We supply A beta peptides of different lengths and point-mutated versions of A beta (1-42) which are known to be related to the familial forms of Alzheimer's disease. They are provided as HFIP-films (HFIP = hexafluoroisopropanol) which removes any unwanted secondary peptide structure and pre-existing oligomeric/polymeric forms.
Available Amyloid beta A4 peptides
Applications of JPT's Amyloid beta peptides (A beta, Beta Amyloid)
- In vitro staining
- Protein-protein interaction studies
- Western Blot
- Binding experiments
"Synthetic Amyloid Beta Peptides Aid Alzheimer Investigation"
by A. Vandersteen et al.
Benefits of JPT's Amyloid beta peptides (A beta, Beta Amyloid)
- All amyloid-ß peptides are well characterized and provided as HFIP-films. This guarantees that all samples contain the same chemically and structurally homogenous material without any unwanted secondary structures
- Production is performed in our German facilities and is ISO 9001:2015 & GCLP certified
- Greatest variety of Abeta sequence modifications in stock - available within days!
- Not found what you are looking for? Request a quote for custom peptide synthesis to obtain your tailored A beta peptide
Testimonial for JPT's Amyloid beta peptides (A beta, Beta Amyloid)
"Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source. We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle.”
Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands
Selected References with JPT's Amyloid beta peptides (A beta, Beta Amyloid)
"Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice"
Hüttenrauch et al., Molecular Neurobiology (2016) - PMID: 27734334
"High Affinity Binding of Monomeric, but not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs"
Thomaier et al., Biochemistry (2016) PMID: n.a.
"A Critical Role For the Self-Assembly of Amyloid-β1-42 in Neurodegeneration"
Marshall et al., Scientific Reports (2016) - PMID: 27443509
"Characterization of Insulin-degrading Enzyme-mediated Cleavage of Aβ in Distinct Aggregation States"
Hubin et al., Biochim Biophys Acta. (2016) - PMID: 26968463
"Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity"
Rudolph et al., PLoS One. (2016) - PMID: 26840229
"Assessment of Structural Properties of Amyloid Aggregates and Their Application Potential"
Thangaraj et al., Dissertation for the University of Ulm (2016) - PMID: n.a.
"Inhibition of the Cardiac Na+ Channel α-subunit Nav1. 5 by Propofol and Dexmedetomidine"
Stoetzer et al., Naunyn Schmiedebergs Arch Pharmacol. - PMID: 26667357
"η-Secretase Processing of APP Inhibits Neuronal Activity in the Hippocampus"
Willem et al., Nature (2015) - PMID: 26322584
"Aβ-42 lowering Agents From the Marine-Derived Fungus Dichotomomyces Cejpii"
Harms et al., Steroids. (2015) – PMID: 26440473
"Hybridization of an Aβ-specific Antibody Fragment with Aminopyrazole-based β Sheet Ligands Displays Striking Enhancement of Target Affinity"
Hellmert et al., Org. Biomol. Chem. (2015)
"Monoclonal Antibodies Against Ab42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in vitro and in Alzheimer's Disease Brain"
Hatami et al., J. Biol. Chem. (2014) - PMID: 25281743
"The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation"
Benilova et al., J. Biol. Chem. (2014) - PMID: 25253695
"Molecular Basis for Increased Risk for Late-onset Alzheimer Disease Due to the Naturally Occurring L28P Mutation in Apolipoprotein E4"
Argyri et al., J. Biol. Chem. (2014) - PMID: 24644280
Reas More References with Amyloid Beta A4 Peptides
JPT's A Beta Peptides Pass the Test!
Read the latest Application Note:
Synthetic Amyloid Beta Peptides
Aid Alzheimer Investigation
by Kerensa Broersen,
University of Twente, Enschede