Cyclic Peptide Library

What Is a Cyclic Peptide Library?

A cyclic peptide library is a structurally diverse collection of peptides that are chemically cyclized into ring-shaped conformations. Cyclization enhances peptide stability by improving resistance to enzymatic degradation and increasing conformational rigidity. This makes them ideal for targeting complex biological processes with high selectivity and potency.

Types of Cyclization Strategies

To generate structurally varied and functionally rich libraries, different cyclization approaches are employed:

Head-to-tail cyclization
Side-chain-to-side-chain
Head-to-side-chain
Side-chain-to-tail

These strategies create macrocyclic structures that often mimic natural protein loops, enabling the discovery of peptides with desirable drug-like properties.

Applications of Cyclic Peptide Libraries

Cyclic peptides are gaining traction in drug development and biological research for their ability to:

Inhibit protein–protein interaction
Block enzymatic activity
Serve as targeted diagnostic or therapeutic agents

Due to their stability and specificity, these libraries are particularly valuable in therapeutic areas such as oncology, infectious disease, and immunotherapy.

JPT’s Expertise in Cyclic Peptide Library Synthesis

With decades of experience, JPT Peptide Technologies offers cutting-edge solutions for cyclic peptide design and synthesis. Our scalable production capabilities support:

Diverse cyclization chemistries (amide, disulfide, etc.)
High-throughput synthesis workflows
High-purity peptide libraries for both screening and validation

JPT enables the rapid generation of high-quality cyclic libraries tailored to the needs of pharmaceutical and academic research. Here you can read more about our Peptide Library and Pool Design Services.

Available Cyclic Peptide Library Formats

Milligram-Scale Libraries

Amount: from 1 mg per peptide
Purity: Crude to 95%
Delivery Format: 96 MTP or Individual Tubes
Customized Modifications

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PepMix Pools

Amount: up to 200 peptides per pool
from 1mg and higher
Purity: Crude to 95%
Each peptide is purified

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Custom Cyclic Peptide Synthesis

Amount: from 1 mg up to gram scale
Purity: Crude to >95%
Format: Customizable upon request
Tailored to your specific research needs

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Why Researchers Trust JPT:

Custom library design using proprietary algorithms
Automated fill-and-finish workflows
Quality-controlled synthesis under restricted regulations
Flexible scales for both milligram and gram quantities

These features make JPT an ideal partner for researchers seeking peptide-based leads for therapeutics, diagnostics, and target validation.