Chelate DOTA Peptides

About DOTA Peptides

DOTA (tetraxetan) is a chelating agent with high affinity for di- and trivalent cations (177Lu, 68Ga, 64Cu) and finds medical application as contrast agent and in cancer treatment. For example, DOTA is bound to radionuclides in peptide receptor radionuclide therapy (PRRT) for the treatment of unresectable neuroendocrine tumors. However, DOTA can be coupled to various molecules and the resulting compounds are used with a number of radioisotopes in cancer therapy and diagnosis (for example in positron emission tomography).

JPT's DOTA Peptides

JPT offers DOTA-peptide precursors off-the shelf with high affinity for somatostatin receptors, which are found on neuroendocrine tumours:
  • DOTATOC (DOTA-(Tyr3)-octreotide or edotreotide) 
  • DOTA-TATE (DOTA-(Tyr3)-octreotate) 
  • DOTA-NOC (DOTA-[Nal3]-octreotide).

Custom DOTA Peptides

JPT also offers custom synthesis of DOTA and NOTA conjugated peptides. JPT can produce large libraries of cyclic peptides including non-natural amino acids (methyl AA, fluoro AA…) for screening applications updown to individual single DOTA peptides in large scale and clinical grade. 
Contact us for an in-depth evaluation of your project or send us a quote request.

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