Peptide optimization is a challenging task that cannot simply be done by the execution of pre-defined general routes. On the contrary, peptide optimization projects require a lot of know-how to choose the best strategy or combination of strategies to address the specific goals of the optimization project.
JPT applies its portfolio of proprietary peptide technologies, bioinformatics and medicinal chemistry know-how, as well as over a decade-long track record managing R&D projects for peptide based contract research and R&D collaborations.
Although no single general strategy for peptide optimization exists, it is clear that such projects often require peptides with reduced conformational flexibility and in later stages also the replacement of peptide amide bonds. JPT is able to provide a wide range of modified peptides for your optimization projects. Depending on your specific needs, we can provide the peptides or actively collaborate with you on the entire project. Please visit our Contract Research Website for details on our R&D services.
Listed below are examples of modified peptides that JPT has produced in the course of optimization projects:
- Non-proteinogenic building blocks, e.g. (constrained) unnatural AAs, N-Alkyl, alpha-Me, beta and gamma amino acids
- Conformational stabilization, e.g. helix/turn stabilization/induction, peptoids, cyclopeptides, e.g. cys-cys, amide, click etc.
- Peptide bond isosters, e.g. aza-AAs, reduced amide