JPT is able to incorporate a wide range of N-terminal modifications into peptides. Examples of modifications routinely synthesized at JPT are shown below.
N-terminal acetylation removes the charge from the amino terminus of a peptide. In general, acetyl modification is recommended if a peptide is meant to imitate its natural structure in a protein. In addition, this modification stabilizes the resulting peptide towards enzymatic degradation resulting from exopeptidases.
Besides acylations, other N-terminal modifications are available (e.g. urea, carbamate, sulfonamide, alkylamine).
If tolerated by the peptides’ pharmacodynamics, radioligands are often attached to the N‑terminus of peptides. Examples include the attachment of DOTA, NOTA, NODAGA, etc..