Pramlintide - Amylin Analog (CAS: 151126-32-8)

Pramlintide is a synthetic analogue of the human hormone Amylin, where the residues at postitions 25, 28, and 29 are replaced with proline. Pramlintide like Amylin has a disulfide bridge between C2 and C7. Amylin is co-secreted with insulin by the pancreas and contributes to glycemic control. For research use only, do not use in humans!

Pramlintide - Amylin Analog (CAS: 151126-32-8) - Specifications

• Peptide sequence: H-KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2, Disulfide
• Amount: 1.0 mg net (AAA)
• Purity: >95% (HPLC-MS)
• Counterion: TFA
• Delivery Format: Freeze-dried in plastic vial
• Chemical formula: C171H267N51O53S2
• MW (average): 3949.44
• Application(s): Diabetes research
• Condition(s)/Topic(s): Diabetes
• Standard Delivery Time: 2-5 days
• CAS: 151126-32-8
• SMILES: O=C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N1CCC[C@H]1C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N2[C@H](C(N3CCC[C@H]3C(N[C@@H]([C@@H](C)O)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)[C@H](O)C)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)CCC2)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CO)[C@H](CC6=CNC=N6)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC7=CC=CC=C7)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)O)NC([C@H](C)NC([C@H]8NC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@H](CSSC8)NC([C@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

JPT’s Amylin Peptides

Amylin 1-37 (or Islet Amyloid Polypeptide, IAPP) is a peptide hormone with the primary sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY. The C-terminus is amidated and it contains a disulfide bridge (2-7) which is necessary for the full biological activity of amylin. Amylin and insulin are co-secreted from pancreatic β-cells. Amylin inhibits glucagon secretion and delays gastric emptying, thus acting as a satiety agent. Amylin can form fibrillar peptide deposits in the islets of Langerhans, which may be related to death of the insulin-producing islet cells in type 2 diabetes. Amylin is also expressed in the human placenta during pregnancy. JPT Peptide Technologies has substantial, long-standing expertise in providing peptides in all formats, scales and modifications to the global scientific community. All our catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.

• All peptides are made in Germany
• Bulk orders or custom peptide synthesis upon request
• Provision of freeze-dried aliquots for enhanced stability
• Proven track record
• Need the conjugated or modified peptide? Contact us!