What are Natriuretic Peptides?
Natriuretic peptides are endogenous peptide hormones that regulate blood pressure, bodyfluid homeostasis, and cardiovascular balance. The main members include atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). They bind to NP-receptors and activate cGMP signaling pathways. This promotes vasodilation, sodium excretion (natriuresis), and water excretion (diuresis), helping to reduce blood pressure and cardiac workload. These peptide hormones are used as important biomarkers and therapeutic targets for cardiovascular diseases.
JPT’s Natriuretic Peptides
JPT offers a comprehensive portfolio of high-quality natriuretic peptides for reproducible cardiovascular research. In addition, customized peptides can be designed by our custom peptide synthesis team to meet specific research needs. Our selection includes the following well-known peptides:
How to Choose the Right Natriuretic Peptide?
The right selection depends on the specific requirements of the experiment and the intended research application. Key factors include peptide type, species, and, mechanism of action.
The following properties and considerations can help guide the selection of the most suitable option for your project:
- Type: This peptide family comprises Atrial, C-Type, and B-Type Natriuretic Peptides. They differ in their tissue of origin, receptor preferences, and physiological roles.
- Species: Different human and animal-derived peptides may vary slightly in sequence and biological activity. This can affect receptor interactions and biological responses.
- Mechanism of Action: Natriuretic signaling hormones act through NP-receptors and cGMP signaling pathways, resulting in different effects such as:
- Physicochemical Properties: Characteristics such as stability, solubility, and susceptibility to enzymatic degradation can influence peptide performance and experimental outcomes.
- Applications: The intended use, such as cardiovascular research, hypertension research, or renal physiology should align with the peptide's biological properties.
- Modifications: Peptides can be customized through terminal modifications, labeling, PEGylation, or sequence optimization to improve stability, detection, and receptor selectivity. Learn more about Peptide Modifications & Specialty Peptides!
Example Natriuretic Peptides
The following table provides examples of natriuretic hormones and summarizes their key characteristics. While sequence differences may exist, these properties are generally conserved among species:
| Peptide | Distinguishing Characteristic | Primary Production Site | Main Receptor Preference | Principal Biological Effects |
| Atrial Natriuretic Peptide (ANP) (1-28) | First isolated from the cardiac atria | Cardiac atria | NPR-A | Vasodilation, natriuresis, diuresis |
| Urodilatin, (ANP 95-126) | Kidney-derived form of ANP | Kidney (distal tubules) | NPR-A | Local regulation of sodium and water excretion |
| Brain Natriuretic Peptide 32 (BNP-32) | First isolated from porcine brain tissue | Cardiac ventricles | NPR-A | Vasodilation, natriuresis, cardiovascular homeostasis |
| C-Type Natriuretic Peptide 1-22 (CNP-22) | Structurally distinct "C-type" peptide | Endothelial cells, chondrocytes, and other peripheral tissues | NPR-B | Vascular regulation, endochondral bone growth, tissue remodeling |
Need a peptide that is not listed? Our custom peptide synthesis team can create a tailored solution for your research.
Research Areas and Applications
Natriuretic peptides are widely used in cardiovascular, renal, and translational research due to their central role in regulating blood pressure, fluid balance, and cardiovascular homeostasis. Through their effects on NP-receptors and cGMP signaling pathways, they provide valuable tools for investigating heart-related physiological and pathological processes.
Common research areas and applications include:
- Cardiovascular disease research
- Heart failure and cardiac stress studies
- Blood pressure regulation and hypertension research
- Renal physiology and fluid homeostasis studies
- Electrolyte and salt-water balance regulation studies
- Water homeostasis and fluid balance research
- NP-receptor signaling investigations
- cGMP-mediated signal transduction research
- Blood vessel function and vascular remodeling investigations
- Vascular biology and endothelial function studies
- Skeletal growth and cartilage development research
- Metabolic syndrome and energy homeostasis studies
- Myocardial remodeling and fibrosis research
- Immune modulation and inflammation studies
- Obesity and insulin resistance research
- Drug discovery and therapeutic development
- Biomarker research and diagnostic blood test development
Why Choose JPT?
JPT Peptide Technologies brings over 20 years of experience in peptide design and manufacturing, supporting researchers across academia, biotechnology, and the pharmaceutical industry worldwide. With a proven track record of delivering millions of high-quality products, JPT has established itself as a trusted partner for reliable and reproducible peptide solutions. All catalog products are provided with HPLC-MS analyses to confirm identity and ensure consistently high quality.
Benefits of JPT s Peptides
- High-throughput synthesis enables efficient and scalable production.
- Manufacturing in Germany ensures stringent quality standards.
- Flexible ordering options include bulk quantities and variable purities.
- Freeze-dried aliquots improve stability and simplify storage.
- Proven expertise is supported by dedicated scientific assistance.
- Cost-effective solutions allow scalability for different project sizes.
- Extensive modification options are available through custom peptide synthesis.
Need help with your project?
Interested in high-quality natriuretic peptides or need assistance selecting the right product for your cardiovascular research? Our customer support team provides guidance on product selection and offers custom peptide synthesis for modified or conjugated designs.
Please contact us or reach out to our scientific support team for personalized assistance. We are here to support your research and help you achieve reliable results.
Are you interested in other products? Explore our extensive peptide catalog for additional research solutions.