MOG (35-55), Mouse Peptide (MEVGWYRSPFSRVVHLYRNGK)

MOG (35-55), Mouse Peptide (MEVGWYRSPFSRVVHLYRNGK) - AA 35 - 55 (= AA 63 - 83 including the signal sequence) for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxity or proliferation assays.

MOG (35-55), Mouse Peptide (MEVGWYRSPFSRVVHLYRNGK) - Specifications

CAS: 163913-87-9
Peptide Name: Myelin Oligodendrocyte Glycoprotein Peptide 35-55, Mouse

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55) | CAS: 163913-87-9

The Myelin Oligodendrocyte Glycoprotein Peptide (35-55), with sequence MEVGWYRSPFSRVVHLYRNGK, is a highly specific peptide derived from the MOG protein's extracellular domain. Known for its significant role in murine models, the peptide is widely used in studies of autoimmune diseases, particularly in research focusing on multiple sclerosis (MS). This peptide is a primary choice in experimental autoimmune encephalomyelitis (EAE) studies, providing invaluable insights into immune responses related to demyelinating diseases like MS.

Applications of MOG35-55 Peptide in Autoimmune Research

The MOG35-55 peptide, recognized by its CAS number 163913-87-9, serves several critical purposes in autoimmune and neurological research. Below are the primary applications and roles of this peptide in scientific studies:

1. Induction of Experimental Autoimmune Encephalomyelitis (EAE)

The MOG35-55 peptide is a standard choice for inducing EAE in mouse models. EAE is a widely accepted model for studying MS, providing researchers with the ability to analyze the mechanisms underlying the disease. By using MOG(35-55) to trigger an autoimmune response, scientists can gain insights into the pathology of MS, including the immune system's attack on myelin sheaths, which leads to demyelination.

2. Advancing Autoimmune Disease Research

MOG (35-55) enables researchers to explore the processes involved in autoimmune diseases such as multiple sclerosis. Its use in research allows scientists to investigate autoimmune pathways, inflammation responses, and mechanisms of myelin degeneration in the central nervous system. This peptide aids in understanding how specific immune responses contribute to the progression of MS and similar disorders.

3. Antigen-Specific T-Cell Stimulation and Immune Response Analysis

This peptide, MOG 35-55, is instrumental in antigen-specific T-cell stimulation. By studying how T-cells respond to myelin antigens, researchers can better understand the immunopathological dynamics of MS. The MOG 35-55 sequence (MEVGWYRSPFSRVVHLYRNGK) is particularly useful for identifying T-cell behaviors, activation pathways, and potential therapeutic interventions to regulate autoimmune responses.

Why MOG peptide is Essential in MS and EAE Research

The MOG peptide serves as a robust tool in MS research, allowing scientists to simulate autoimmune conditions that affect the nervous system. Due to its high specificity for murine EAE models, MOG 35-55 has become indispensable for:


• Analyzing immune responses in murine systems

• Developing potential treatments targeting immune-mediated demyelination

• Assessing interventions aimed at protecting or regenerating myelin sheaths


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