MOG (35-55), Mouse Peptide (MEVGWYRSPFSRVVHLYRNGK)

The MOG 35-55 peptide is a well-characterized immunodominant peptide derived from myelin oligodendrocyte glycoprotein. The sequence MEVGWYRSPFSRVVHLYRNGK is widely used to induce experimental autoimmune encephalomyelitis (EAE) in mouse models, making it a standard tool for studying multiple sclerosis and CNS demyelination.

Due to its strong and reproducible activation of antigen-specific CD4+ T cells, MOG35-55 (CAS Nr. 163913-87-9) is commonly applied in neuroimmunology to investigate inflammatory signaling, immune cell infiltration, and disease progression in the central nervous system. Its consistent performance in EAE induction makes it a reliable reference peptide for preclinical autoimmune research.

The Mouse Myelin-oligodendrocyte glycoprotein Peptide is a high quality epitope peptide for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxicity or proliferation assays. The Myelin-oligodendrocyte glycoprotein Peptide, H-MEVGWYRSPFSRVVHLYRNGK-OH (Uniprot: Q61885 aa: 35-55 (aa: 63-83)) from JPT is produced under strict quality control and quality management.

MOG (35-55), Mouse Peptide (MEVGWYRSPFSRVVHLYRNGK) - Specifications

• Peptide sequence: H-MEVGWYRSPFSRVVHLYRNGK-OH
• Amount: 1 mg
• Purity: Trial Grade: each peptide purified to > 90% (HPLC/MS)
• Delivery Format: Freeze-dried in plastic vial
• Application(s):
• Condition(s)/Topic(s):
• Standard Delivery Time: 2-5 days

CAS: 163913-87-9
Peptide Name: Myelin Oligodendrocyte Glycoprotein Peptide 35-55, Mouse

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Applications of MOG 35-55 in Autoimmune Research

Induction of Experimental Autoimmune Encephalomyelitis (EAE)

MOG 35-55 is widely used to induce EAE in mice, providing a robust and reproducible model for studying autoimmune-mediated demyelination. This model enables detailed analysis of immune mechanisms relevant to multiple sclerosis.

Antigen-Specific T-Cell Activation

The peptide is suitable for controlled stimulation of antigen-specific T cells and is commonly used in ELISPOT, intracellular cytokine staining (ICS), cytotoxicity, and proliferation assays. It supports detailed characterization of T-cell responses and cytokine profiles.

Investigation of CNS Inflammation and Demyelination

MOG 35-55 is applied to study inflammatory signaling, immune cell infiltration, and myelin damage within the central nervous system. It provides a consistent experimental framework for evaluating disease mechanisms and therapeutic strategies.

Your Custom or Scrambled Antigen Peptide!