MHC I & II Multimers
T cells recognize specific MHC-peptide complex displayed on the surface of antigen-presenting cells. This specific interaction is used by MHC multimers carrying MHC-peptide complexes to detect and isolate antigen-specific T cell. Fluorescent-labeled MHC multimers are used to detect, quantify and isolate antigen-specific T cells in fluid samples (e.g. blood, cultured cell lines, CSF, lymph, synovial fluid) by flow cytometry, and for in situ detection (e.g. in solid tumors) by immunohistochemistry (IHC).
Find the related Antigen Peptide for each MHC Multimer or order your antigen by custom peptide synthesis!
- Stabilizing dextran polymer backbone
- Fluorochrome molecules
- More MHC-peptide complexes than conventional MHC multimers (such as tetramers)
- Stronger staining intensity
- Increased resolution and signal-to-noise ratio
MHC Dextramers detect the presence of antigen-specific T cells whereas interferon-gamma-releasing assays such as ELISpot detect the functionality of the antigen-specific T cells. Thus, a combination of the MHC Dextramer assay and an interferon-gamma-releasing assay, using PepMix™ Peptide Pools as specific stimulating antigens, is an effective tool for reliable and robust immune monitoring!
Individual MHC I Dextramers®
More than 400 different MHC I Dextramers® are available!
Selection of available Alleles:
|Human alleles||Mouse alleles||Monkey alleles|
Individual MHC II Dextramers®
Fluorescent MHC II multimers available with three different fluorochromes and many alleles, e.g.
MHC I Dextramer® Collections
MHC I Multimer Collections are carefully selected sets of multimers (Dextramers®) for staining and isolation of antigen-specific CD8+ T cells. They are available for a variety of viruses and tumors with different fluorochromes (APC, PE, FITC), e.g.
- Cancer-testis antigens
- Virus antigens
Custom MHC Mutlimers
Fast delivery of custom MHC Dextramers® upon request.
All production is performed according to ISO 9001:2015 standards.