Women Who Received Varicella Vaccine Versus Natural Infection Have Different Long-Term T Cell Immunity but Similar Antibody Levels

Products & Services
Catalog
- PepMix™ Peptide Pools
  PepMix™ Peptide Pools
  Pools of overlapping peptides from antigenic proteins for T-cell stimulation, T-cell expansion in T-cell assays such as ELISPOT, ICS or Flow Cytometry, e.g. for immune monitoring.
- Transduction Enhancer
  
  Transduction Enhancer
  Protransduzin™ the highly efficient transduction enhancer increases viral gene transfer in pre-clinical and clinical applications, such as ex vivo gene therapy and CAR-T cell development.
- Antigen Peptides
  - COVID-19 Antigen Peptides
  - Further Antigen Peptides
  Antigen Peptides
  Antigen peptides represent specific epitopes for stimulation of T cells in T cell assays such as ELISPOT. We offer the corresponding MHC multimer for each antigen peptide. Antigens from different pathogens are available as well as tumor associated antigens.
- MHC Multimers
  MHC Multimers
  MHC Multimers for reproducible detection, enumeration and isolation of antigen-specific T cells with disease specific peptides.
- Proteomics Peptides & Kits
  Proteomics Peptides & Kits
  Peptide sets and pools, as well as assay standardization kits are available with stable isotope labeled or unlabeled proteotypic peptides for mass-spectrometry based proteomics such as MRM assays.
- RepliTope™ Peptide Microarrays
  RepliTope™ Peptide Microarrays
  Peptide microarrays that display overlapping peptide scans through antigens from infectious organisms or tumor associated antigens for antibody or serum profiling.
- Chelate Peptides (DOTA)
  
  Chelate Peptides (DOTA)
  DOTA is linked to molecules that have affinity for various structures (e.g. somatostatin receptors in neuroendocrine tumors). The resulting compounds can be bound to radionuclided and are used with a number of radioisotopes in cancer therapy and diagnosis
- Cosmetic Peptides (DPRA Peptides)
  
  Cosmetic Peptides
  Cosmetic Peptides such as Lysine and Cysteine Peptide are used for DPRA (Direct Peptide Reactivity Assay) for Skin Sensitization Testing. The DPRA measures the reaction of a chemical with synthetic peptides containing Cysteine (Ac‑RFAACAA‑COOH) or Lysine (Ac‑RFAAKAA‑COOH) to assess its sensitization potency. For research use only!
- Immunology Standards & Controls
  - Control Peptide Pools
  - TERS Reference Samples
  Immunology Standards & Controls
  Standards and controls for reproducible T-cell assays such as ELISPOT and multimer assays. We offer a large variety of positive and negative control peptide pools for antigen specific T cell stimulation as well as kit to produce TCR-engineered reference samples for performance control.
- Abeta & Prion Peptides
  - Amyloid Beta A4 Peptides
  - Major Prion Peptides
  Abeta & Prion Peptides
  Purified, fully analyzed, high quality peptides, synthesized from the peptide experts for Alzheimers and prion research.
- Assay Services
  
  Assay Services
  We offer our extensive know-how and experience in peptide microarray incubation & data evaluation as full-service packages for many applications.
- Enzyme Substrates
  Enzyme Substrates
  Large collections of peptidic enzyme substrates in microtiter plates or displayed on microarrays for screening and enyzme profiling.
- Histone Peptide Tools
  Histone Peptide Tools
  Our histone peptide library is the largest on the market and available as Peptide ELISA, Peptide Microarray or sets of histone peptides
Contract Research
Company
- - JPT has a work force of >100 highly trained and skilled employees. 30 of our co-workers hold a university degree and 20 have a PhD in natural sciences.
News & Publications
Support & Contact
- - We take pride in our competent service and swift response. Please do not hesitate to contact us for further information. We also very much welcome your feedback and comments.

Women Who Received Varicella Vaccine Versus Natural Infection Have Different Long-Term T Cell Immunity but Similar Antibody Levels

Ellen Tourtelot et.al., Vaccine (2020) - PMID: 31959424

Product(s) used in this publication: PepMix™ Peptide Pools

Abstract

BACKGROUND:

Varicella-zoster virus (VZV) infection during pregnancy is associated with serious fetal anomalies. The live-attenuated VZV vaccine was approved in 1995, so many vaccinated women are now of childbearing age. The question of long-term immunity to varicella is critical because breakthrough chickenpox can occur after vaccination.

OBJECTIVE:

To compare humoral and T cell immunity between women of childbearing age who were immunized by vaccination or chickenpox disease.

STUDY DESIGN:

Non-pregnant females between 18 and 36 years old with a history of VZV immunization (n = 20) or prior chickenpox disease (n = 20) were recruited. IgG antibody titers and T cell responses were measured by flow cytometry-based methods in serum and peripheral blood, respectively.

RESULTS:

There were no significant differences in median antibody titers between vaccinated and chickenpox groups (p = 0.34). The chickenpox group had significantly higher levels of VZV antigen-specific CD4 T cells (p = 0.004).

CONCLUSION:

Natural infection induced higher VZV-specific T cell immune responses than vaccination.

Search

All Our Publications