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Individuals with Inherited Chromosomally Integrated Human Herpes Virus 6 (ciHHV-6) Have Functionally Active HHV-6 Specific T-cell Immunity

Strenger et al., Clinical Microbiology and Infection (2016) - PMID: 26482270

Product(s) used in this publication: PepMix™ Peptide Pools

Abstract:

To evaluate the human herpes virus 6 (HHV-6) -specific immune response in individuals with chromosomally integrated HHV-6 (ciHHV-6), we measured HHV-6-antigen-specific cytokine responses (interferon-γ, interleukin-2, tumour necrosis factor-α) in T cells by flow cytometry in 12 and 16 individuals with and without ciHHV-6, respectively. All individuals with ciHHV-6 showed HHV-6-specific T cells with higher frequencies of HHV-6-specific CD8(+) cells (0.03-14.93, median 2.15% of CD8(+) cells) compared with non-ciHHV-6 (0.0-10.67, median 0.36%, p 0.026). The observed increased HHV-6-specific functionally active responses in individuals with ciHHV-6 clearly disprove speculations on immune tolerance in ciHHV-6 and indicate clinical and immunological implications of ciHHV-6.

Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

KEYWORDS:

Chromosomal integration; HHV-6; T-cell response; U54; cytomegalovirus

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