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Lack of Confirmation of Anti-inward Rectifying Potassium Channel 4.1 Antibodies as Reliable Markers of Multiple Sclerosis

Nerrant et al., Mult Scler. (2014) - PMID: 24756568

Product(s) used in this publication:  Peptide ELISA

Abstract:

BACKGROUND:

auto-antibodies against the potassium channel inward rectifying potassium channel 4.1 (Kir4.1) have previously been identified in 46% of patients with multiple sclerosis (MS).

OBJECTIVES:

to confirm these findings.

METHODS:

we evaluated the presence of anti-Kir4.1 antibodies by enzyme-linked immunosorbent assay (ELISA) and immunofluorescence in 268 MS patients, 46 patients with other neurological diseases (OND) and 45 healthy controls.

RESULTS:

anti-Kir4.1 antibodies were found in 7.5% of MS patients, 4.3% of OND patients and 4.4% of healthy controls. Immunofluorescence analysis did not identify any specific staining.

CONCLUSIONS:

we confirmed the presence of anti-Kir4.1 antibodies in MS patients, but at a much lower prevalence than previously reported.

© The Author(s), 2014.

KEYWORDS:

ELISA; Kir4.1 antibody; Multiple sclerosis; biomarker; diagnosis

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