Aβ-42 lowering Agents From the Marine-Derived Fungus Dichotomomyces Cejpii

Harms et al., Steroids. (2015) - PMID: 26440473

Product(s) used in this publication:  Amyloid Beta A4 Peptides

Abstract:

The ascomycete Dichotomomyces cejpii was isolated from the marine sponge Callyspongia cf. C. flammea. Three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin X dimethyl ether (4). Compounds 2 and 4 were evaluated in an Alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in Aftin-5 treated cells. Aβ-42 lowering agents are considered as candidates for the treatment of neurodegenerative Alzheimer's disease.

Copyright © 2015 Elsevier Inc. All rights reserved.

KEYWORDS:

Alzheimer’s disease; Dichotomomyces cejpii; Ergosterol derivatives

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