Zika virus (ZIKV) belongs to the flaviviruses such as dengue virus, West Nile virus, yellow fever virus, Saint Louis encephalitis virus and tick-borne encephalitis virus. Flaviviruses carry a positive-sense, single-stranded RNA and most flaviviruses are transmitted by the bite from an infected arthropod (mosquito or tick).
We offer specific Zika virus peptides, Zika peptide pools and Zika peptide microarrays (ZIKV peptides, ZIKV peptide pools, ZIKV peptide microarrays).
- Transmitted by the mosquitoes A. aegypti and A. albopictus
- Was first isolated in 1947 from the Zika Forest of Uganda
- From 2007 the virus spread across the Pacific Ocean to South America, leading to the Zika virus epidemic
- Zika virus causes Zika fever or Zika virus disease
- Usually shows no or only mild symptoms
- Zika can also spread from a pregnant women to the fetuses
- Causes microcephaly, severe brain malformations, and other birth defects in unborn children
Cellular Immune Response
JPT offers tailored custom peptides, peptide libraries and peptide pools for research on Zika virus and other flaviviruses. We provide knowledgeable support, high quality, flexible and innovative formats combined with expert know-how to bring forward your research project.
- Immune monitoring of high-risk patients
- Qualification of immunodominant antigens
- Validating clinical T-cell assays
PepMixes™ Zika Virus ULTRA
As sequence diversity among viruses is is important for all research and development efforts, we created a new algorithm to reflect sequence diversity within our peptide libraries, peptide pools and peptide microarrays. PepMix™ ULTRA pools are generic, all-inclusive peptide libraries with an optimized coverage of all sequence variations. The new ULTRA algorithm creates all possible peptide variations and scores these according to their frequency of occurrence across all sequences. We can then define the optimal overlap required to provide homogeneous overall coverage. Currently available Ultra PepMixes™ are:
PepMix™ Yellow fever (NS4B)
Pool of 60 peptides derived from a peptide scan through Non-structural protein 4B (Swiss-Prot ID: P03314) of Yellow fever virus. PepMix™ Peptide Pools make use of a common peptide library format, where a single antigen is represented by 15 amino acid peptides with 11 amino acid overlap.
Tailored PepMix™ Peptide Pools
Peptide Pools tailored for your specific needs!
- High-throughput T-cell epitope discovery
- Monitoring of cellular immune response
- Clinical trials
We are the experts for peptide synthesis with highest quality optimized for many applications. Our peptide synthesis service has a very high success rate (over 99%) as we optimize the appropriate peptide synthesis method for each peptide.
If you would like to order a quality peptide synthesis using regulated processes, choose JPT!
Humoral Immune Response
- Immune monitoring of humoral responses
- Profiling of EBV specific samples or antibodies
- Evaluation of co-infection
- Detection of epitopes and epitope spreading
Catalog RepliTope™ Antigen Collection Ultra
As sequence diversity among viruses is is important for all research and development efforts, we created a new algorithm to reflect sequence diversity within our peptide libraries, peptide pools and peptide microarrays resulting in generic, all-inclusive peptide libraries with an optimized coverage of all sequence variations. The new ULTRA algorithm creates all possible peptide variations and scores these according to their frequency of occurrence across all sequences. We can then define the optimal overlap required to provide homogeneous overall coverage.
RepliTope™ Antigen Collection Pan-Flavivirus Ultra (Zika)
Peptide microarray displaying 6253 peptides derived from selected proteins of ZIKA virus, Dengue virus, West Nile virus, Yellow fever virus and Saint Louis encephalitis virus
Catalog RepliTope™ Peptide Microarrays
Ready-made peptide microarrays displaying overlapping peptides through single immunodominant antigens available in standard format (incubation with 1 sample) or multiwell format (incubation with 21 samples):
- RepliTope™ Dengue Virus (Capsid protein)
- RepliTope™ Dengue Virus (Envelope protein)
- RepliTope™ Dengue Virus (Membrane glycoprotein)
- RepliTope™ Dengue Virus (Nonstructural protein 1)
- RepliTope™ Dengue Virus (Nonstructural protein 3)
- RepliTope™ West Nile virus (Envelope glycoprotein E)
- RepliTope™ Yellow fever (NS4B)
Catalog RepliTope™ Antigen Collection
The RepliTope™ Antigen Collection combines overlapping peptides for all the proteins above on one microarray for optimal coverage of the most important antigens in a single experiment.
> RepliTope™ Peptide Microarrays Product Page
Tailored PepStar™ Peptide Microarrays
You define content and layout, we provide economic and fast production in our regulated clean-room environment. We also offer our assay and analysis service using your samples with your tailored peptide microarray.
Our tailored Peptide ELISA plates are offered as stand-alone service for mapping of epitopes and definition of protein interaction sites or as validation assay to confirm results obtained with JPT’s peptide microarrays.
JPT’s Clinical Peptides product lines Clinical Grade and ISO Plus are produced in production environments that are regulated by an enhanced ISO 9001:2015 quality management system for the stringent product requirements of immunotherapy as well as vaccine and drug development. Depending on the specifics of the immunotherapy concept to be applied, the resulting products have been shown to be applicable in clinical applications.
"Generation of Zika Virus-Specific T Cells from Seropositive and Virus-Naïve Donors for Potential Use as an Autologous or "Off-the-Shelf" Immunotherapeutic"
Hanajiri et al, Cytotherapy (2019)
"Vaccine Protection Against Zika Virus from Brazil"
Larocca et al., Nature (2016) PMID: 27355570
"Protective Efficacy of Multiple Vaccine Platforms Against Zika Virus Challenge in Rhesus Monkeys"
Abbink et al., Science (2016) PMID: 27492477
"Mapping the Sequence Space of ZIKA and Related Viruses: High-Content Peptide Libraries for Immune Monitoring" Von Hoegen et al., Conference Poster (2016)
The Challenge of Antigen Sequence Diversity: Solutions with ULTRA-Peptide Libraries
Reimer et al., - Application Note (2016)
More application notes