Peptide Tools to Study EBV
About EBV (Epstein-Barr Virus)
Epstein-Barr virus (EBV or HHV-4) belongs to the family of Herpesviridae and is known as the cause of infectious mononucleosis. Being able to establish a long-term, latent infection in human B cells, it is prevalent in the adult population (worldwide 90%).
EBV is associated with a range of human diseases and cancers:
- Hodgkin’s and Burkitt’s lymphoma
- Nasopharyngal carcinoma
- Main cause of post-transplant lymphoproliferative disease (PTLD) in immune suppressed transplant patients
- Increases the risk of certain autoimmune diseases, e.g. lupus erythematosus, rheumatoid arthritis and multiple sclerosis
- Plays a role in the development of chronic fatigue syndrome (CFS)
The latent EBV Antigens
During latent infection EBV expresses a small number of genes (e.g. EBNA1 -3 and LMP1 -2). Three major types of latency can be differentiated by their distinct expression patterns and are associated with the various types of diseases and cancer. Both, humoral and cellular (mainly CTL) immune responses play a role in controlling the primary and the latent phases of EBV infection.
JPT's Peptide Tools to Study EBV (Epstein-Barr Virus):
Selected EBV Related References
"Evaluation of EBV- and HCMV-Specific T Cell Responses in Systemic Lupus Erythematosus (SLE) Patients Using a Normalized Enzyme-Linked Immunospot (ELISPOT) Assay"
Cassaniti et al, Journal of Immunology Research (2019)
"Measurement of CD8.sup.+ and CD4.sup.+ T Cell Frequencies Specific for EBV LMP1 and LMP2a Using mRNA-Transfected DCs"
Dae-Hee Sohn et al, PLoS ONE (2019)
"T-Cell Responses Targeting HIV Nef Uniquely Correlate With Infected Cell Frequencies After Long-Term Antiretroviral Therapy"
Thomas et al, PLoS Pathogens (2019)
"PRAME Peptide‐Specific CD8+ T Cells Represent the Predominant Response Against Leukemia‐Associated Antigens (LAAs) in Healthy Individuals"
Matko et al, European Journal of Immunology (2018)
"Dynamics of Virus‐Specific T Cell Immunity in Pediatric Liver Transplant Recipients"
Arasaratnam et al, American Journal of Transplantation (2018)
"Epstein-Barr Virus (EBV)-derived BARF1 Encodes CD4-and CD8-restricted Epitopes as Targets for T-cell Immunotherapy"
Kalra et al, Cytotherapy (2018)
Selected EBV Related Testimonials
"My group is developing therapeutic strategies for using in vitro expanded virus-specific T cells (VSTs) for the treatment of viral infections in immunocompromised patients. We recently demonstrated the feasibility and clinical benefit associated with the infusion of rapidly generated single-culture VSTs, manufactured using JPT's GxP PepMix™ peptide pools covering 12 immunogenic antigens from five viruses (EBV, AdV, CMV, BK, and HHV6). When administered to 11 allogeneic stem cell transplant recipients, 8 of whom had up to four active infections, these VSTs produced an overall 94% response rate."
Ann Leen, PhD, Baylor College of Medicine, Houston, TX, USA
"The main focus of my research group at the Charité in Berlin is the development of novel immunotherapeutic approaches against cancer and infectious diseases. For reliable monitoring of tumor and virus specific T-cell responses we have a permanent need for peptides and peptide pools that are produced in a regulated environment for application in a clinical environment. JPT has been a long term and dedicated partner in this regard which continuously works on improving it's peptide based services."
Prof. Dr. Carmen Scheibenbogen, Charité Berlin, Germany
More testimonials
Selected EBV Related Application Notes
Peptide-stimulated Expansion of Virus-specific T cells for Preventative Treatment after Allogeneic Stem Cell Transplantation
Gary et. al, Apllication Note (2015)
Multiple Sclerosis and Epstein‐Barr Virus Infection - An Epitope Mapping Study
Reimer et al., Application Note (2014)
BioTides™ as High Throughput Screening Tool for the Identification of Antibody Binding Sites
Kuehne et al., Application Note (2012)
A Modular Approach for Epitope Discovery and High-Resolution Profiling of Humoral Immune Responses
Pawlowski et al., Application Note (2013)
PepMix™ Peptide Pools for Clinical Applications
Keirnan et al., Application Note (2012)
More application notes
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Quality Assurance
All production is performed according to ISO 9001:2015 standards