 - Lenomorelin (CAS 258279-04-8).jpg "Ghrelin (human) - Lenomorelin (CAS: 258279-04-8)")
SP-CAT-045
Ghrelin (human) or Lenomorelin is an endogenous GHS-R agonist (secretagogue receptor agonist) that is mainly produced in the stomach. Ghrelin includes a post-translational modification at position 3 (serine is acylated with an octanoic acid). This acylation is essential for Ghrelin to bind to the GHS-R. Upon binding to its receptor, ghrelin promotes fat storage and stimulates the release of growth hormone. For research use only, do not use in humans!
Ghrelin or lenomorelin is a hormone primarily produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach and is often called a "hunger hormone" because it increases the drive to eat. For proper function and GHS receptor binding Ghrelin needs to be post-translationally modified at serine 3, which is acylated with an octanoic acid. JPT Peptide Technologies has substantial, long-standing expertise in providing peptides in all formats, scales and modifications including post-translational modifications to the global scientific community. All our catalog peptides are provided with HPLC-MS analyses to confirm the identity and demonstrate the high quality of our peptides.
Benefits of JPT’s PeptidesReferences:
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Testimonial:
"Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle."
Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands
Testimonial:
Our group focuses on the in vitro study of risk factors in Alzheimer’s disease and, as we experienced that the in-house expression and production of the amyloid beta peptide is notoriously difficult, we are continuously dependent on a high quality supply of a large variety of these peptides from commercial source.We started our collaboration with JPT with their request to test a range of their peptides for the ability to produce toxic oligomers and fibrillar networks and were impressed by the rapid supply of a very wide range of high purity peptides with excellent fibril forming properties and toxicity profiles. JPT has shown real valuable know-how and experience in the field of peptide synthesis by their ability to generate high quality preparations of amyloid beta peptide variants which are known for their difficulty to handle.
Kerensa Broersen, Assistant Prof., Nanobiophysics Group, University of Twente, Enschede, The Netherlands
| Properties | Values |
|---|---|
| Amount: | 1.0 mg net (AAA) |
| Application: | Diabetes research |
| Category: | Diabetes Peptides |
| Condition / Topic: | Diabetes |
| Layout: | Freeze-dried in plastic vial |
| Organism: | Human |
| Protein Name: | Diabetes Peptide |
| Purity: | >95% (HPLC-MS) |
| Quantification: | Yes |
| Information | Values |
|---|---|
| Sequence: | H-GS-Ser(n-Octanoyl)-FLSPEHQRVQQRKESKKPPAKLQPR-OH |
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